Results 41 to 50 of about 12,439 (266)

Methods of calculating the belt foundation on the elastic ground base of winkler type [PDF]

E3S Web of Conferences, 2019
Strip foundations on an elastic soil foundation and on a Winkler-type elastic foundation were used in the construction of buildings and structures from the most common types of shallow foundations.
Lastovka Anatoly, Danchenko Tamara, Klinduh Nadezhda, Berseneva Maria   +3 more
doaj   +1 more source

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

British Journal of Clinical Pharmacology, EarlyView.
Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E64d in healthy volunteers.
Sebastian Fähndrich, Franziska Friedrich, Daniel Soriano, Jona Gjeloshi, Björn C. Frye, Xuan Phuoc Nguyen, Lydia Herbstritt, Caroline von Spee‐Mayer, Britta Lang, Fabrice Nollevaux, Andreas Hoheisel, Dorothee Winterberg, Armin Braun, Thomas Epting, Christine Contini, Karl Winkler, Thomas Reinheckel, Franziska C. Trudzinski, Gernot Rohde, Daiana Stolz, Robert Bals, Martin J. Hug, Sebastian Wirtz, Christoph Peters, Carolin Jenkner   +24 more
wiley   +1 more source

Scalable Separation and Purification of M13‐Bacteriophage‐Derived Particles Containing Artificial Single‐Stranded DNA Produced by Escherichia coli

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Single‐stranded DNA (ssDNA) solutions are promising innovations shaping the future of genetic research and medical therapies. In principle, biotechnological mass production of ssDNA can be achieved using Escherichia coli in a high‐cell density fed‐batch process by secreting phagemid particles derived from the filamentous M13 bacteriophages ...
Nathalie Hafner, Wiebke Winkler, Maximilian N. Honemann, Hendrik Dietz, Dirk Weuster‐Botz   +4 more
wiley   +1 more source

Autonomous Control of Gene Expression Using Endogenous Transcription Signals

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Autonomous cell‐based control of heterologous gene expression can simplify batch‐culture bioprocessing by eliminating external monitoring and extrinsic control of culture conditions. Existing approaches use auto‐induction media, synthetic cell‐cell communication systems, or application‐specific biosensors.
Pakpoom Subsoontorn, Drew Endy, Olivier Borkowski   +2 more
wiley   +1 more source

VIBRATION OF BEAMS, LYING ON THE SOLID NONLOCAL ELASTIC FOUNDATION

Structural Mechanics of Engineering Constructions and Buildings, 2016
Now, the calculation of beams, lying on the solid elastic foundation is fulfilled with us- ing different model of elastic foundation. One of the most common is a model, based on the hypothesis of a proportion betweenthe reaction of the foundation at the ...
A A Vasilenko
doaj  

Appropriateness of the Winkler foundation in modeling soil vibrations induced by rail transit

Journal of Low Frequency Noise, Vibration and Active Control
The vibration problem caused by rail transit involves the dynamic interaction between the train, track, roadbed, and surrounding strata. Establishing a comprehensive numerical model that includes all these components is a complex task.
Dong Li, Hongkai Wang, Jili Yin, Zhoujian You, Qin Xu, Futong Wang   +5 more
doaj   +1 more source

Effect of soil subgrade modulus on raft foundation behavior

MATEC Web of Conferences, 2017
The present study is carried out to investigate the effect of soil subgrade modulus on bending moment, shear, and deformation characteristics of raft foundation.
Mughieda Omer, Mehana Mohamed Sherif, Hazirbaba Kenan   +2 more
doaj   +1 more source

Achieving Carbon Neutrality: Strategic Pathways to Sustainability and Net Zero in Manufacturing Supply Chains

Business Strategy and the Environment, EarlyView.
ABSTRACT Reaching global net‐zero targets has become an urgent priority as businesses and nations face increasing pressure to reduce greenhouse gas emissions. Achieving carbon neutrality in manufacturing supply chains requires comprehensive systemic changes across business processes.
Vimal K. E. K., Sivakumar K., Jayakrishna Kandasamy, Umesh Kumar, Anil Kumar, Ashutosh Samadhiya   +5 more
wiley   +1 more source

Conceptualizing Corporate Political Activity for Sustainability Governance—The CPA Cube

Business Strategy and the Environment, EarlyView.
ABSTRACT Sustainability transformations in the economy, and related public policy decisions, are highly contested, attracting business involvement. To better understand how business influence on government impacts the success or failure of sustainability governance efforts, this paper extends the literature on corporate political activity (CPA) by ...
Burkard Eberlein, Janina Grabs
wiley   +1 more source

How B Corp Leaders Engage Stakeholders in the Development of B Corp Strategies: Evidence From the Italian Context

Business Strategy and the Environment, EarlyView.
ABSTRACT As companies increasingly define success by measures beyond financial returns, leaders in recent decades have faced a pressing challenge: translating stakeholder‐driven purpose into sustainability strategies that employees genuinely understand and enact.
Lucia Gatti, Dario Risso, Ralf Wagner
wiley   +1 more source