Results 21 to 30 of about 128,052 (317)

Investigating the Marginal and Herd Effects of COVID-19 Vaccination for Reducing Case Fatality Rate: Evidence from the United States between March 2021 to January 2022

open access: yesVaccines, 2023
Vaccination campaigns have been rolled out in most countries to increase vaccination coverage and protect against case mortality during the ongoing pandemic.
Tenglong Li   +3 more
doaj   +1 more source

Unconventional Wisdom [PDF]

open access: yesCell, 2009
Science is an "endless frontier," and opportunities for transformative discovery abound. The young scientist will profit by paying mind to two forms of balance: the contrast between depth and breadth in training, and the contrast between hypothesis-driven research and random inquiry into the unknown.
openaire   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Fine classification of rice fields in high-resolution remote sensing images

open access: yesScientific Reports
Fine-grained management of rice fields can enhance the yield and quality of rice crops. Challenges in achieving fine classification include interference from similar vegetation, the irregularity of natural field shapes, and complex scale variations. This
Lingyuan Zhao   +4 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Association between housework frequency and cognitive impairment among Chinese older adults: a prospective cohort study based on CLHLS

open access: yesBMC Public Health
Background Housework is a crucial aspect of instrumental activities of daily living (IADL), essential for maintaining the independence of older adults.
Zhenni Wang   +3 more
doaj   +1 more source

Learner2Vec-Based Learner Community Evolution Analysis–A Case Study Involving Student Card Data

open access: yesIEEE Access, 2019
The learner community evolution analysis is an important technique in the area of social network analysis and education management. Accurately expressing the complex characteristics of individual social behavior is the core problem associated with ...
Chao Li   +4 more
doaj   +1 more source

analytical study about Reviews recent thinkers of the imaginary Perception in the perspective of Mullasadra [PDF]

open access: yesحکمت صدرایی, 2019
In transcendence wisdom, the essence of the knowledge and the mechanism of its grasping to human soul passed from epistemology and entered to ontology. Mulla Sadra has innovations in intellectual and universal conceptions and imaginary perceptions, which
Mohammadali Vatandoost Haghighi Marand   +1 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Effect of Different Adjuvants on the Immunogenicity of a Recombinant Herpes Zoster Vaccine in Mice, Rats and Non-Human Primates

open access: yesVaccines
Background: Varicella zoster virus (VZV) is a globally circulating pathogen that usually infects children and establishes a latent state in host nerve cells.
Xiaoyang Liu   +9 more
doaj   +1 more source

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