Results 31 to 40 of about 196,075 (302)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Effect of Different Adjuvants on the Immunogenicity of a Recombinant Herpes Zoster Vaccine in Mice, Rats and Non-Human Primates

Vaccines
Background: Varicella zoster virus (VZV) is a globally circulating pathogen that usually infects children and establishes a latent state in host nerve cells.
Xiaoyang Liu, Shaohua Gong, Jingyi Xu, Ying Wei, Xuyan Chen, Yucheng Wu, Zhengli Zhang, Junyu Ma, Yili Yang, Shuhua Tan   +9 more
doaj   +1 more source

Investigating the Marginal and Herd Effects of COVID-19 Vaccination for Reducing Case Fatality Rate: Evidence from the United States between March 2021 to January 2022

Vaccines, 2023
Vaccination campaigns have been rolled out in most countries to increase vaccination coverage and protect against case mortality during the ongoing pandemic.
Tenglong Li, Zilong Wang, Shuyue He, Ying Chen   +3 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science
Clinical translation of engineered exosomes, an emerging class of cell therapies, is hampered by challenges in each step of the manufacture flow, namely biogenesis, cargo loading, isolation, and storage.
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
doaj   +1 more source

TPP-Thiazole Derivatives Ameliorate Psoriasiform Inflammation by Glycolysis Inhibition

Molecules
Psoriasis, a chronic inflammatory skin disease, is driven by immune dysregulation and keratinocyte hyperproliferation, with current biologics facing limitations.
Xinwei Meng, Ci-An Cheng, Zhirui Zhang, Siying Qu, Anqi Zhang, Yang Zhang, Jinxin Gu, Hanwen Zhang, Keyue Ding, Lei Fu, Mengchen Lu, Daiyun Huang, Yixue Qiao   +12 more
doaj   +1 more source

A Comparative Study of Conjecture from the Point of View of Ibn Sina and Mulla Sadra [PDF]

تاریخ فلسفه اسلامی
Ibn Sina is one of the first Muslim philosophers who discussed conjecture and what it is in a systematic way in his works. In this article, by using analytical-comparative method, the basic question is answered, what is the difference between Mulla Sadra'
Mahmud Saidiy, Hossein Zamaniha
doaj   +1 more source

analytical study about Reviews recent thinkers of the imaginary Perception in the perspective of Mullasadra [PDF]

حکمت صدرایی, 2019
In transcendence wisdom, the essence of the knowledge and the mechanism of its grasping to human soul passed from epistemology and entered to ontology. Mulla Sadra has innovations in intellectual and universal conceptions and imaginary perceptions, which
Mohammadali Vatandoost Haghighi Marand, seyyed mortaza Hoseini shahrudi   +1 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source