Results 51 to 60 of about 281,017 (295)

A pearl of wisdom

open access: yesThe British Journal of Radiology, 1991
An 8-year-old girl presented with progressive unsteadiness on her feet over a 2-year period. She was otherwise fit and well. No neurological deficit was found on examination, but movements of the lumbar spine were reduced. Conventional radiographs of the lumbar spine, myelogram and computed tomography (CT) myelographic findings are demonstrated in Figs
J, Rawlinson, C L, Coblentz, S, Franic
openaire   +2 more sources

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif   +17 more
wiley   +1 more source

Fluktuationen in der Geschichte: Ein kurzer Abschied von den langen Wellen

open access: yesÖsterreichische Zeitschrift für Geschichtswissenschaften, 2007
The article reconstructs the important influence of cycle theories on the explanation of processes in business and society after Kondratieff and Schumpeter.
Karl H. Müller
doaj   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias   +3 more
wiley   +1 more source

Spatio-temporal modelling of extreme low birth rates in U.S. counties

open access: yesBMC Public Health
The continuous declining rate of birth may cause severe worldwide problems, including population ageing and demographic imbalance. This paper aims to identify the geographic disparities and potential influential factors of the extreme downward excess of ...
Kai Wang   +4 more
doaj   +1 more source

Variation in breeding practices and geographic isolation drive subpopulation differentiation, contributing to the loss of genetic diversity within dog breed lineages

open access: yesCanine Medicine and Genetics, 2020
Background Discrete breed ideals are not restricted to delimiting dog breeds from another, but also are key drivers of subpopulation differentiation. As genetic differentiation due to population fragmentation results in increased rates of inbreeding and ...
Sara Lampi   +3 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

The ecology of wisdom [PDF]

open access: yes
This is the first of two papers concerning wisdom as an ecosystem appearing in sequential editions of Management & Marketing journal. The notion of wisdom as an ecosystem, or “the wisdom ecology,” builds on work by Hays (2007) who first identified wisdom
J. Martin HAYS
core  

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay   +15 more
wiley   +1 more source

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