Results 61 to 70 of about 254,224 (295)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

The ecology of wisdom [PDF]

open access: yes
This is the first of two papers concerning wisdom as an ecosystem appearing in sequential editions of Management & Marketing journal. The notion of wisdom as an ecosystem, or “the wisdom ecology,” builds on work by Hays (2007) who first identified wisdom
J. Martin HAYS
core  

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay   +15 more
wiley   +1 more source

A grid frequency estimation method based on moving average filter half-tangent phase-locked loop

open access: yesDiance yu yibiao
This paper proposes a half-tangent phase-locked loop (HTan-PLL) with a moving average filter (MAF) for estimating grid frequency. The proposed PLL utilizes a half-tangent phase detector (PD) and introduces MAF into the phase-locked loop to address ...
WANG Wenguo, ZHANG Ben
doaj   +1 more source

Arthur Godfrey's Talent Scout Show in New York City

open access: yes, 1957
Scrapbook by Diane Wisdom containing letters, telegrams, newspaper clippings, tickets, and other ephemera from the events of May 16, 1957 when Diane Wisdom is accepted into Arthur Godfrey's Talent Scout Show to fan mail postmarked August 02, 1957 after ...
Wisdom, Diane
core  

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno   +19 more
wiley   +1 more source

Translation and Validation of a Vietnamese Version of the Colorectal Cancer Subscale for the Functional Assessment of Cancer Therapy - Colorectal Questionnaire

open access: yesSAGE Open Nursing
Introduction There is a need for a validated Vietnamese translation of the colorectal cancer subscale (CCS) of the functional assessment of cancer therapy–colorectal (FACT-C) questionnaire to assess colorectal cancer-specific concerns of Vietnamese ...
Thi Hong Hanh Tran PhD   +2 more
doaj   +1 more source

Analytical Examination of the Philosophical Correlations between "Self-Knowledge" and "Knowledge of the Lord" with a Focus on the Relationship between Soul and Body [PDF]

open access: yesحکمت اسرا
One of the most important traditions regarding the connection between self-knowledge and the knowledge of God is the tradition "He who knows himself knows his Lord." This narration has been examined, explained, and analyzed by many Muslim thinkers. Among
Mohammad Javad Jafari Zadeh   +2 more
doaj   +1 more source

Evaluation of Dried Plasma Spot‐Based Quantification of Glial Fibrillary Acidic Protein as a Disease‐Associated Biomarker in Neuromyelitis Optica Spectrum Disorder

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the diagnostic accuracy of glial fibrillary acidic protein (GFAP) measured in dried plasma spots versus conventional plasma‐ and serum‐GFAP testing for assessment of disease severity in aquaporin‐4 immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD).
Felix Wohlrab   +19 more
wiley   +1 more source

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