Results 101 to 110 of about 584,417 (340)

An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model

open access: yesNature Communications, 2017
DNA-delivered monoclonal antibodies (DMAbs) can be produced by muscle cells in vivo, potentially allowing prevention or treatment of infectious diseases.
Ami Patel   +21 more
doaj   +1 more source

The Establishment of Metabolic Syndrome Model by Induction of Fructose Drinking Water in Male Wistar Rats

open access: yesBioMed Research International, 2014
Background. Metabolic syndrome can be caused by modification of diet by means of consumption of high carbohydrate and high fat diet such as fructose. Aims.
Norshalizah Mamikutty   +5 more
semanticscholar   +1 more source

Shear Stress Targeted Delivery of Nitroglycerin to Brain Collaterals Improves Ischaemic Stroke Outcome

open access: yesAdvanced Science, EarlyView.
Shear‐activated nanoparticles carrying nitroglycerin selectively target high‐shear stress collateral vessels during ischaemic stroke, enhancing blood flow to at‐risk brain without systemic side effects. This novel approach significantly improves outcomes in animal models, outperforming conventional nitroglycerin delivery.
Magdalena Litman   +21 more
wiley   +1 more source

Learned helplessness and social avoidance in the Wistar-Kyoto rat

open access: yesFrontiers in Behavioral Neuroscience, 2014
The Wistar-Kyoto (WKY) rat is an established depression model characterized by elevated anxiety- and depression-like behavior across a variety of tests. Here we further characterized specific behavioral and functional domains relevant to depression that ...
H. Nam   +3 more
semanticscholar   +1 more source

Female and male Wistar rats (Rattus norvegicus) discriminate diets according to energetic quantity [PDF]

open access: yes, 2020
The food choice of animals is influenced by several factors including the quantity and nutrients available. It is not known, however, whether faced with alternatives that present the same amount of food, with similar flavor and obtained with the same ...
Aragon, Davi Casadele   +4 more
core  

Oral Administration of Peppermint in Wistar Albino Rats: Memory Boosting and Regaining [PDF]

open access: yes, 2013
The studies on peppermint aroma fluence on cognition are numerous. However the knowledge about oral consumption of peppermint and cognition was inadequate. Hence the present study was undertaken to find out the effect of oral administration of peppermint
Jasira, M. (M)   +2 more
core   +2 more sources

Differential Sensitivity to Morphine in Spontaneously Hypertensive and Normotensive Wistar-Kyoto and Wistar Rats

open access: yesClinical and Experimental Hypertension. Part A: Theory and Practice, 1987
In spontaneously hypertensive rats (SHR) a diminished responsiveness for nociceptive stimuli is present, which might be associated with alterations in endogenous opioid peptide and receptor systems. In SHR, normotensive Wistar-Kyoto controls (WKY) and in Wistar rats the effects of acute morphine administration on pain sensitivity and body temperature ...
Frans P. Nijkamp   +2 more
openaire   +3 more sources

Molecular Design of a Naturally Derived Hemostatic Sealant with Prolonged Antimicrobial Activity for Repairing Elastic Organ Injuries

open access: yesAdvanced Science, EarlyView.
An injectable, photocrosslinkable hydrogel sealant—comprising GelMAG, DMA, and pDDA—demonstrated strong underwater adhesion, elasticity, biocompatibility, and broad‐spectrum antibacterial activity. This material rapidly sealed dynamic internal organ injuries and significantly reduced blood loss in vivo. Its superior performance over commercial products
Saumya Jain   +6 more
wiley   +1 more source

Targeting CARM1 in ovarian cancer with EZH2 and PARP inhibitors

open access: yesMolecular & Cellular Oncology, 2020
Coactivator-associated arginine methyltransferase 1 (CARM1)-expressing high-grade serous ovarian cancers are characterized by poor prognosis and limited therapeutic options.
Sergey Karakashev, Rugang Zhang
doaj   +1 more source

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

open access: yesPLoS ONE, 2011
The cofactor nicotinamide adenine dinucleotide (NAD+) has emerged as a key regulator of metabolism, stress resistance and longevity. Apart from its role as an important redox carrier, NAD+ also serves as the sole substrate for NAD-dependent enzymes ...
N. Braidy   +5 more
semanticscholar   +1 more source

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