Results 191 to 200 of about 391,386 (289)

454 Checkpoint modification of early T cell activation provides enhanced anti-tumor activity and survival benefits in a fast-growing preclinical tumor challenge model

Journal for ImmunoTherapy of Cancer, 2023
Sue L Currie, Mohsen Mohammadi, Xiang Y Zhou, Zhi Xiang, Wynetta Giles-Davis, Andrew Luber, Hildegund CJ Ertl   +6 more
doaj   +1 more source

Prenatal Developmental Toxicity of ARVIDEX® Herbal Medicine in Albino Wistar Rats. [PDF]

Cureus
Engeu Ogwang P, Joshua K, Katende P, Arisinga TR, Kyomugisha S, Neeza T, Terkimbi SD, Mekuriya Yadesa T, Mwandah DC.   +8 more
europepmc   +1 more source

Blood-brain barrier disruption and perivascular beta-amyloid accumulation in the brain of aged rats with spontaneous hypertension: Evaluation with dynamic contrast-enhanced magnetic resonance imaging [PDF]

, 2018
Chen, Wei, Gao, Fabao, Song, Li, Tao, Chuanyuan, Wang, Chunhua, Wang, Yu, Xu, Ziqian, Zhang, Ruzhi, Zheng, Jie   +8 more
core   +2 more sources

Maternal exercise improves vascular function in hypertensive offspring via A‐kinase anchoring protein 150 gene (Akap5) epigenetic modifications

British Journal of Pharmacology, EarlyView.
Background and Purpose Regular physical activity is an effective non‐pharmacological approach to hypertension management and maternal exercise improves offspring cardiovascular health, although mechanisms remain unclear. A‐kinase anchoring protein 150 (AKAP150) targets protein kinase Cα to L‐type Ca2+ channels (CaV1.2), enhancing vascular tone in ...
Fang Qiu, Yanyan Zhang, Meiling Shan, Jiaqi Cao, Zihan Fan, Zhaoxia Xu, Xiaozhen Ding, Xiaodong Liu, Lijun Shi   +8 more
wiley   +1 more source

Dasatinib resensitizes BRAF/MEK inhibitor efficacy in patient-derived xenografts from patients with progression on BRAF/MEK inhibitor treatment. [PDF]

iScience
Rebecca VW, Xiao M, Kossenkov A, Godok T, Brown GS, Fingerman D, Alicea GM, Wei M, Ji H, Portuallo M, Bravo J, Elad V, Chen Y, Toska E, Fane ME, Couts KL, Villanueva J, Nathanson K, Arun KM, Warrier G, Yin X, Ding J, Liu Q, Goyal Y, Gopal YNV, Davies MA, Herlyn M.   +26 more
europepmc   +1 more source

Feedback control of excitability and high K+ induced epileptiform bursts in male rat hippocampal slices with a photocaged adenosine A1 receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Adenosine is a potent regulator of neurotransmission and neuronal excitability, through activation of Gi coupled adenosine A1 receptors (A1Rs). Adenosine has gained interest as an anticonvulsant because of its endogenous involvement in ending seizure activity, but peripheral side effects require local application.
Erine Craey, Marijke Vergaelen, Serge Van Calenbergh, Jeroen Spanoghe, Evelien Carrette, Kristl Vonck, Paul Boon, Wytse J. Wadman, Robrecht Raedt   +8 more
wiley   +1 more source

Dorzagliatin shows potential in preventing cognitive impairment in diabetes: evidence from Mendelian randomization analysis and animal study. [PDF]

Front Endocrinol (Lausanne)
Ni J, Wang K, Feng L, Wang C, Li C, Chen Y, Chen L.   +6 more
europepmc   +1 more source

Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity

British Journal of Pharmacology, EarlyView.
Background and Purpose Dopamine receptor agonists, particularly targeting the dopamine D2L receptor (D2LR), have been used to treat Parkinson's disease (PD). However, valvular heart disease and somnolence, mainly caused by activating the serotonin 5‐HT2B receptor (5‐HT2BR) and dopamine D3 receptor (D3R), respectively, currently challenge their clinical
Takayuki Suzuki, Fumiki Oana, Masaki Oota, Yuma Handa, Osamu Kaminuma   +4 more
wiley   +1 more source

Stair-climbing resistance exercise, with or without oral turmeric (Curcuma longa L.) supplementation, relieves symptoms and promotes musculoskeletal repair in experimental rheumatoid arthritis in rats. [PDF]

J Muscle Res Cell Motil
Kuhn MG, da Silva LM, da Silva FH, de Jesus MCL, Gossler M, Cappellaro GL, Bertolini GRF, de Fátima Chasko Ribeiro L, Guimarães ATB, Torrejais MM.   +9 more
europepmc   +1 more source

Differential effects of ketamine enantiomers on EEG parameters including the gamma‐delta shift phenomenon

British Journal of Pharmacology, EarlyView.
Background and Purpose Ketamine consists of two enantiomers, (R)‐ketamine and (S)‐ketamine, which exhibit distinct pharmacological properties. Currently, only the (S)‐enantiomer has been approved for the treatment of major depressive disorder, whereas recent clinical studies have failed to demonstrate an antidepressant effect for (R)‐ketamine.
Szabolcs Koncz, Dóra Pothorszki, Noémi Papp, Donát Pál, György Bagdy   +4 more
wiley   +1 more source