Results 121 to 130 of about 244,251 (336)

An algorithm for seizure detection in rodents

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy animal research often relies on long‐term intracranial electroencephalographic (iEEG) recordings. Here, we describe an artificial neural network (ANN) algorithm for automatic detection of seizures. Methods The algorithm was trained on iEEG recordings of three mouse models of chronic epilepsy: (1) the pilocarpine model of ...
Lyna Kamintsky, Gerben van Hameren, Itai Weissberg, Pooyan Moradi, Ofer Prager, Alaa Abu Ahmad, Lior Schori, Albert Becker, Yaniv Zigel, Alon Friedman   +9 more
wiley   +1 more source

The hematobiochemical status of Wistar rat line under the bovine leukemia virus experimental infection [PDF]

, 2019
E S Krasnikova, Fayssal Bouchemla, Alexander V. Krasnikov, R. V. Radionov, A. S. Belyakova   +4 more
openalex   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) rats.

PLoS ONE, 2014
Regenerating (REG) proteins are associated with islet development, β-cell damage, diabetes and pancreatitis. Particularly, REG-1 and REG-3-beta are involved in cell growth/survival and/or inflammation and the Reg1 promoter contains interleukin-6 (IL-6 ...
Sophie Calderari, Jean-Claude Irminger, Marie-Hélène Giroix, Jan A Ehses, Marie-Noëlle Gangnerau, Josiane Coulaud, Katharina Rickenbach, Dominique Gauguier, Philippe Halban, Patricia Serradas, Françoise Homo-Delarche   +10 more
doaj   +1 more source

A ‘Humanized’ rat model of pre-diabetes by high fat diet-feeding to weaning wistar rats [PDF]

, 2015
Young male Wistar rats weighing (40-50 g) were used in this study. They were maintained at standard environmental conditions that is temperature 25 ± 2°C, relative humidity 50-55% and 12/12 hours light & dark cycles. After one week of acclimatization period, rats was fed with HFD (Rodent diet # D12451, Research Diet, Inc., New Brunswick) enriched with 45% fat that was fed on normal standardized diet without additional fat. The rats were fed HFD continuously for 6 months periods. Body weight, fasting and 2-h blood glucose was monitored every month. At 0, 4 and 6 months blood samples were collected from fasting anesthetized rats for the measurement of serum insulin, total cholesterol, HDL-cholesterol and triglyceride level. Additionally, epididymal fat pads were rapidly isolated. After isolation, half of the tissue was rapidly frozen in liquid nitrogen and kept at -80°C until mRNA analysis. The other half of the tissue was rapidly washed with warm phosphate buffer pH 7.4 and immediately put for the isolation of adipocytes. At the end of experimental periods, the rats were sacrificed and a portion of the pancreas from the same anatomical location (splenic) from each rat was taken and fixed in 10% buffered formalin and processed for immunohistochemical analysis. Insulin and glucagon immunostaining as well as morphometry was done as described earlier [13,14]. Serum was separated from the collected blood samples for the determination of biochemical parameters. All animals were treated according to the guidelines for care and use of laboratory animals with the approval of Institutional Ethics Committee of the ICCBS, University of Karachi, Pakistan.   +13 more
openalex   +1 more source

Papric Ethanol Extract Test (Capsicum Annuum) on Blood Sugar Levels of Wistar Rat (Rattus Norvegicus) Induced Alloxan

, 2021
Dara Ananda, Pratama Zendrato, Edlin, Andre Budi   +3 more
openalex   +1 more source

Hepatic Insulin Resistance Model in the Male Wistar Rat Using Exogenous Insulin Glargine Administration [PDF]

, 2023
Víctor Enrique Sarmiento-Ortega, Diana Moroni-González, Alfonso Díaz, Miguel Garcia-Gonzalez, Eduardo Brambila, Samuel Treviño   +5 more
openalex   +1 more source

Epilepsy surgery: From bench to the clinics

Epilepsia Open, EarlyView.
Abstract Objective Recent advances in epilepsy surgery in patients with intractable epilepsy make it possible to study the mechanism of epilepsy in human brains. However, the true extent and propagation of each epileptogenic area from the epileptogenic focus in each patient is still difficult to perform “epilepsy cure” by surgery.
Tatsuya Tanaka
wiley   +1 more source

Clock gene dysregulation in epilepsy: A systematic review

Epilepsia Open, EarlyView.
Abstract Objective Epileptic seizures show a rhythmic pattern, being more frequent at particular times of the day (e.g., only occurring during sleep), suggesting a role of the circadian rhythm. Clock genes regulate the circadian rhythm and might be involved in the pathophysiology of epilepsy.
Guilherme Fernandes‐Campos, Arjune Sen, Francesca Panin, Krithika Sundararaman   +3 more
wiley   +1 more source

Evaluating the Effects of Moringa Oleifera Leaf Extract on Testosterone Level of Male Wistar Rats Exposed to Petrol, Diesel and Kerosene

Sokoto Journal of Medical Laboratory Science
Testes are primary organ of reproduction as they are responsible for the production and release of testosterone. Testosterone is the major androgenic steroid hormone produced primarily in the Leydig cells, it has both intratesticular and peripheral ...
Bashir Saidu', Ashiru Dahiru', Aliyu Jibril’, Ahmad Musa Dunfawa', Nafisat Abdulazeez' and Muawiyyah Muhammad Mahuta’
doaj