Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions
Sensory Neuroscience, EarlyView.ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang +7 more
wiley +1 more source
Comparative Efficacy of Pioglitazone, Saroglitazar, and Silymarin on Biochemical and Histopathological Hepatic Outcomes in a Wistar Rat Model of Non-alcoholic Fatty Liver Disease and Their Correlation With Insulin Sensitivity. [PDF]
CureusJain I, Nath R, Kumar M, Pal R, Dixit R.
europepmc +1 more source
In Vitro Reconstruction of Axonal Heat Sensing with a Photothermal Nerve‐on‐a‐Chip
Small, EarlyView.A photothermal nerve‐on‐a‐chip platform is presented that enables precise, localized heating of sensory axons with simultaneous electrical recording. The system reveals millisecond‐scale dynamics of heat‐evoked neural activity and provides a new approach to study how temperature‐dependent ion channel behavior is translated into axonal firing.
Koji Sakai +6 more
wiley +1 more source
Two-Stage Microwave Hyperthermia Using Magnetic Nanoparticles for Optimal Chemotherapy Activation in Liver Cancer: Concept and Preliminary Tests on Wistar Rat Model. [PDF]
Cancers (Basel)Schreiner OD +3 more
europepmc +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Prostate cancer (PCa) is an endocrine‐related cancer highly dependent on androgenic signaling. Beyond hormone dependence, extrinsic factors play a significant role in the risk of developing PCa, which raises concern about the influence of environmental compounds such as endocrine‐disrupting chemicals (EDCs). Tributyltin (TBT) is an EDC used in
Mariana Feijó +9 more
wiley +1 more source
Subcellular localization of the P2X4 receptor in sensory hair cells of Wistar rat cochlea. [PDF]
Histochem Cell BiolHuang Z +7 more
europepmc +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Mining plays a crucial role in economic development, but improper management can lead to severe environmental degradation. Particularly for iron ore, mining generates vast amounts of tailings often stored in unstable dams. This study aims to investigate the toxicological impacts of environmentally relevant concentrations of metals mixture ...
Kalinka Helóra Gomes de Almeida +7 more
wiley +1 more source
Maternal Lead Exposure Induces Glandular Alterations in the Salivary Glands of Rat Male Offspring
Environmental Toxicology, EarlyView.ABSTRACT Lead (Pb) is a widely distributed environmental pollutant that is highly noxious due to its toxicokinetic characteristics. Pb exposure can damage vital organ systems, including the central nervous and stomatognathic systems. As salivary glands play an important role in oral homeostasis, this study aimed to investigate the effects of maternal ...
Rayssa Maitê Farias Nazário +8 more
wiley +1 more source
Voluntary Running and Estrous Cycle Modulate ΔFOSB in the Suprachiasmatic Nucleus of the Wistar Rat. [PDF]
J Circadian RhythmsShiba A +9 more
europepmc +1 more source
An Experimental Study on the Protective Effect of Memantine in Noise‐Induced Hearing Loss
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Objective This study examined the potential protective effects of memantine, an N‐methyl‐D‐aspartate (NMDA) receptor antagonist, against acoustic trauma (AT) in guinea pigs, using electrophysiological and histopathological analyses. Methods Thirty guinea pigs with normal hearing were divided into six groups (n = 5 per group): Group 1 (control),
Begüm Arda +6 more
wiley +1 more source