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MODELING AND SYNTHESIS OF THE WISTAR RAT ELECTROCARDIOGRAM
Journal of Biological Systems, 2023In this work, we present a synthesizer of electrocardiographic signals of the experimental model of the Wistar rat. Firstly, we modeled the P, R, and S waves using Gaussian functions, while for the T-wave, we used a Gumbel function. We validated the proposed model using a Wistar rat electrocardiogram database, which contains 41 animals with 62,907 ...
Caracciolo, Santiago Federico +2 more
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Acetaminophen nephrotoxicity in male Wistar rats
Archives of Toxicology, 1992Acute acetaminophen (APAP) nephrotoxicity was studied in male Wistar rats 1 h after different APAP single doses (200, 500 and 1000 mg/kg body wt, i.p.). Significant impairments in glomerular filtration rate (GFR) and clearance of p-aminohippuric acid (ClPAH) were observed in a dose-dependent way, although tubular parameters measured, water and ...
L, Trumper, G, Girardi, M M, Elías
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Induced palatal candidosis in the Wistar rat
Archives of Oral Biology, 1981Palatal candidosis was induced by inoculating Candida albicans 3091 (serotype A) under an acrylic appliance. After 1 week, the palatal epithelium showed acute inflammatory cell infiltration and surface colonization by blastospores. Two weeks after inoculation, the inflammation had increased, micro-abscesses were observed and fungal hyphae penetrated ...
B S, Shakir, M V, Martin, C J, Smith
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Developmental Toxicity of Homobrassinolide in Wistar Rats
International Journal of Toxicology, 2010Brassinosteroids (BRs) are close analogues of animal cholesterol. Brassinosteroids have shown their great value as yield promoters of a variety of plants. In view of its steroidal moiety and recent use in agriculture in many countries, the teratogenic potential of homobrassinolide (HBR) was evaluated in Wistar rats. Homobrassinolide was administered by
Yogeshkumar V, Murkunde +1 more
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Hepatotoxicity of graphene oxide in Wistar rats
Environmental Science and Pollution Research, 2020Graphene oxide (GO) has a multitude of applications in areas of nanomedicine, electronics, textile, water purification, and catalysis among others. GO is relatively easier to manufacture and customize as compared with other carbon-based nanomaterials.
Naresh K. Nirmal +2 more
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Subchronic Toxicity of Pentostatin in Wistar Rats
Toxicologic Pathology, 1994Pentostatin, an adenosine deaminase inhibitor, has been approved for the treatment of refractory hairy cell leukemia. In a preclinical toxicity study, Wistar rats were administered 0, 1, 10. 25, and 50 mg/kg (0, 6, 60, 150, and 300 mg/m 2 , respectively) pentostatin intravenously once a week ...
C L, Courtney +2 more
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A revaluation of the haemoglobin electrophoretogram of the wistar rat
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1971Abstract 1. 1. Haemoglobins of Wistar rats have been examined by starch and polyacrylamide gel electrophoresis 2. 2. Two haemoglobins are produced during yolk sac erythropoiesis, and two additional haemoglobins appear during liver erythropoiesis. 3. 3. All four haemoglobins persist in the adult. 4. 4.
A R, Shaw, N, Maclean
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Anticholinesterasic Activity of Endosulfan in Wistar Rats
Bulletin of Environmental Contamination and Toxicology, 2011The in vivo and in vitro effects of the pesticide endosulfan on the cholinesterase (ChE) activity were investigated in rats. ChE activity decreased in dams and in male pups within 65 days corresponding to 35% and 32% of inhibition respectively in the higher endosulfan dose (1.5 mg/kg).
Helena Cristina, Silva de Assis +6 more
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Toxicology Reference Data for the Wistar Rat
1982Sixty-six observations on Wistar rats, including body and organ weights, biochemistry, hematology, and urinalysis have been compiled over a period of 16 years. A statistical analysis of these observations involved 3,400 Wistar rats that served as controls in toxicity studies.
P J, Lewi, R P, Marsboom
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Tumor-Induced Anorexia in the Wistar Rat
Science, 1981The transplantable Leydig cell tumor of Wistar rats, LTW(m), caused decreased food consumption and weight loss in the host within 2 weeks of implantation. The tumor was small, did not metastasize, and did not affect several parameters of biochemical function.
J P, Mordes, A A, Rossini
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