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Chronic Oral D-Galactose Induces Oxidative Stress but Not Overt Organ Dysfunction in Male Wistar Rats. [PDF]
Curr Issues Mol BiolMartinovic J +6 more
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Wistar rat dermis recellularization
Research in Veterinary Science, 2020Skin lesions are normal to all species, regardless of gender or age. The skin, the largest organ of the body, has function as a primary barrier to the chemical, physical and biological aggressions of the environment. In animals, these lesions may be due to fights and/or predations, also as in humans, there is a very common cause of dermal lesions that ...
Gustavo de Sá Schiavo Matias +4 more
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Ameloblastoma in a female Wistar rat
Experimental and Toxicologic Pathology, 1995A spontaneous ameloblastoma of the right mandible is described in a 120-week-old female Wistar rat (strain Chbb: THOM). The tumour had a locally aggressive growth pattern and was histologically characterized by sheets and islands of odontogenic epithelium bounded by a palisaded layer of ameloblast-like cells. Because of multifocal keratinizing squamous
Dumitru Mirea, Heinrich Ernst
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Endocardial Schwannomas in the Wistar Rat
Journal of Veterinary Medicine Series A, 2005SummaryEndocardial neoplasms were observed in 13 Wistar rats, 15–30 months old, from a 30‐month inhalation study. Eight of the rats were dissected at 30 months and the other five between 15 and 29 months. Histologically, the lesions in the heart were diagnosed as endocardial schwannomas.
A. Teredesai, T. Wohrmann
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Genotoxicity of nimesulide in Wistar rats
Drug and Chemical Toxicology, 2013It is mandatory for all new drugs to be tested for their potential genotoxicity in addition to general toxicity testing. Some old drugs have not been tested adequately for their genotoxic effects because these were in use before the local regulations were enforced. According to the material safety database, the toxicological effect of nimesulide is not
Subas Chandra Parija +3 more
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Spontaneous Immunoglomerulonephritis in Wistar Rats
Pathology - Research and Practice, 1980A strain of rats bred at the Nuclear Study Center of Mol (C.E.N.) develops a nephropathy characterized by granular deposition of immunoglobulin and complement in the renal glomeruli and tubules. We have attempted to specify the complement activation pathways (classical or alternate) in this disease by looking for their initial components (C1q, C3 and ...
Angela Fridman-Manduzio +2 more
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METABOLISM OF MYOSMINE IN WISTAR RATS
Drug Metabolism and Disposition, 2005The alkaloid myosmine is present not only in tobacco products but also in various foods. Myosmine is easily nitrosated, yielding 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) and the esophageal tobacco carcinogen N'-nitrosonornicotine. Due to its widespread occurrence, investigations on the metabolism and activation of myosmine are needed for risk ...
Stefan Tyroller +2 more
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Spontaneous Neoplasms in Control Wistar Rats
Toxicological Sciences, 1994Neoplastic data on 1370 control Wistar rats from 10 carcinogenicity bioassays done between 1980 and 1990 were reviewed. Mean percentage survival at 104 weeks was 58% for males and 59% for females. A total of 1857 neoplasms were diagnosed in 466 (68%) male and 582 (85%) female rats; 1390 were benign and 467 were malignant (12% with metastasis).
James Poteracki, Kathleen M. Walsh
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