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Hematological Characteristics of the BB Wistar Rat
Veterinary Clinical Pathology, 1983SummaryComplete blood counts, differential white blood cell and platelet counts were performed on male and female BB Wistar diabetic rats (BBWd), their nondiabetic siblings (BBWnd) and outbred Wistar rats of the line from which the BB Wistar rats were derived.
James R. Wright +5 more
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Subchronic Toxicity of Pentostatin in Wistar Rats
Toxicologic Pathology, 1994Pentostatin, an adenosine deaminase inhibitor, has been approved for the treatment of refractory hairy cell leukemia. In a preclinical toxicity study, Wistar rats were administered 0, 1, 10. 25, and 50 mg/kg (0, 6, 60, 150, and 300 mg/m2, respectively) pentostatin intravenously once a week for 26 wk (1.5-75-fold above the therapeutic dose in humans ...
Cynthia L. Courtney +2 more
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Developmental Toxicity of Homobrassinolide in Wistar Rats
International Journal of Toxicology, 2010Brassinosteroids (BRs) are close analogues of animal cholesterol. Brassinosteroids have shown their great value as yield promoters of a variety of plants. In view of its steroidal moiety and recent use in agriculture in many countries, the teratogenic potential of homobrassinolide (HBR) was evaluated in Wistar rats.
Yogeshkumar V. Murkunde +1 more
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Anticholinesterasic Activity of Endosulfan in Wistar Rats
Bulletin of Environmental Contamination and Toxicology, 2011The in vivo and in vitro effects of the pesticide endosulfan on the cholinesterase (ChE) activity were investigated in rats. ChE activity decreased in dams and in male pups within 65 days corresponding to 35% and 32% of inhibition respectively in the higher endosulfan dose (1.5 mg/kg).
Paulo Roberto Dalsenter +6 more
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Teratogenic Effect of Semicarbazide in Wistar Rats
Neonatology, 1986Five groups of pregnant Wistar rats were injected intraperitoneally with a single dose of semicarbazide (SC) on day 5, 7, 10, 13, or 15 of gestation. The lots in each group received either 50, 75, 100 or 150 mg/kg SC. A sixth group received 17 mg/kg of the drug during the entire course of pregnancy.
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Teratogenicity of ionic cadmium in the Wistar rat
Archives of Toxicology, 1987In rats of the present (re-derived) Wistar-Porton strain that are dosed either intravenously (i.v.), or intraperitoneally (i.p.) with Cd (1.25 mg/kg body weight) on day 12 of gestation (gd 12), foetal uptake of Cd is at least 6-fold greater than that reported in an earlier study (Webb and Samarawickrama 1981).
D. Holt, M. Webb
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Antidiabetic Activity of Afobazole in Wistar Rats
Bulletin of Experimental Biology and Medicine, 2018Using the streptozotocin model of type 2 diabetes mellitus in Wistar rats, we compared antidiabetic activity of anxiolytic Afobazole with that of metformin. Afobazole in a dose of 10 mg/kg reduced streptozotocin-induced hyperglycemia and polyphagia and prevented accumulation of malonic dialdehyde, being not inferior to metformin in a dose of 300 mg/kg,
M V Voronin +5 more
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Lymphoproliferative lesions in BB Wistar rats
Metabolism, 1983Fifteen percent of long-term diabetic BB Wistar rats developed abdominal B cell lymphoproliferative lesions which ranged from minute mesenteric aggregates of plasma cells and lymphocytes to malignant lymphoma with features of immunoblastic sarcoma or plasma-cell lymphoma.
W. Schürch +7 more
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Toxicology Reference Data for the Wistar Rat
1982Sixty-six observations on Wistar rats, including body and organ weights, biochemistry, hematology, and urinalysis have been compiled over a period of 16 years. A statistical analysis of these observations involved 3,400 Wistar rats that served as controls in toxicity studies.
P. J. Lewi, R. P. Marsboom
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