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Acetaminophen nephrotoxicity in male Wistar rats
Archives of Toxicology, 1992Acute acetaminophen (APAP) nephrotoxicity was studied in male Wistar rats 1 h after different APAP single doses (200, 500 and 1000 mg/kg body wt, i.p.). Significant impairments in glomerular filtration rate (GFR) and clearance of p-aminohippuric acid (ClPAH) were observed in a dose-dependent way, although tubular parameters measured, water and ...
L, Trumper, G, Girardi, M M, Elías
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The fate of oxalic acid in the Wistar rat
Xenobiotica, 19811. An established procedure for determining oxalate in human urine has been modified for rat urine. The daily excretion of oxalate by the male Wistar rat is 570-650 microgram. 2. Oxalate excretion in rat urine following i.p. administration of [14C]oxalic acid (1-70 mg/kg) has been studied. The rate and degree of excretion are dose-dependent. 3.
A R, Jones, P, Gadiel, D, Stevenson
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Resistance to mineralocorticoids in Wistar-Furth rats
American Journal of Physiology-Heart and Circulatory Physiology, 1997Wistar-Furth rats (WF) do not develop hypertension when treated with salt and mineralocorticoids and therefore may be useful for investigating the mechanisms of mineralocorticoid action and hypertension. In the present studies, we determined vascular and renal responses of WF to mineralocorticoids. Control Wistar rats (W) developed deoxycorticosterone
M E, Ullian +5 more
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Transplantation of the Interfrontal Suture in the Wistar Rat
Cells Tissues Organs, 1982By excising a 3-day-old interfrontal suture with adnexa and transplanting it into the sagittal suture of a 10-week-old rat of the same inbred strain, the development of the interfrontal suture under experimental conditions could be studied. The effect was a distinct delay of the moment of closure of the suture, namely, from normal period of 1 week to ...
H A, Oudhof, I S, Markens
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Polymorphism in Diazepam Metabolism in Wistar Rats
Journal of Pharmaceutical Sciences, 2004We observed variations in the metabolism of diazepam in Wistar rats. We studied these variations carefully, and found that the variations are dimorphic and about 17% of male rats of Wistar strain we examined showed two times higher diazepam metabolic activities in their liver microsomes than the rest of animals at the substrate concentrations less than
Konomu, Saito +5 more
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Teratogenicity of ionic cadmium in the Wistar rat
Archives of Toxicology, 1987In rats of the present (re-derived) Wistar-Porton strain that are dosed either intravenously (i.v.), or intraperitoneally (i.p.) with Cd (1.25 mg/kg body weight) on day 12 of gestation (gd 12), foetal uptake of Cd is at least 6-fold greater than that reported in an earlier study (Webb and Samarawickrama 1981).
D, Holt, M, Webb
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Subchronic Toxicity of Pentostatin in Wistar Rats
Toxicologic Pathology, 1994Pentostatin, an adenosine deaminase inhibitor, has been approved for the treatment of refractory hairy cell leukemia. In a preclinical toxicity study, Wistar rats were administered 0, 1, 10. 25, and 50 mg/kg (0, 6, 60, 150, and 300 mg/m2, respectively) pentostatin intravenously once a week for 26 wk (1.5-75-fold above the therapeutic dose in humans ...
C L, Courtney +2 more
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Hematological Characteristics of the BB Wistar Rat
Veterinary Clinical Pathology, 1983SummaryComplete blood counts, differential white blood cell and platelet counts were performed on male and female BB Wistar diabetic rats (BBWd), their nondiabetic siblings (BBWnd) and outbred Wistar rats of the line from which the BB Wistar rats were derived.
J R, Wright +5 more
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A revaluation of the haemoglobin electrophoretogram of the wistar rat
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1971Abstract 1. 1. Haemoglobins of Wistar rats have been examined by starch and polyacrylamide gel electrophoresis 2. 2. Two haemoglobins are produced during yolk sac erythropoiesis, and two additional haemoglobins appear during liver erythropoiesis. 3. 3. All four haemoglobins persist in the adult. 4. 4.
A R, Shaw, N, Maclean
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Anticholinesterasic Activity of Endosulfan in Wistar Rats
Bulletin of Environmental Contamination and Toxicology, 2011The in vivo and in vitro effects of the pesticide endosulfan on the cholinesterase (ChE) activity were investigated in rats. ChE activity decreased in dams and in male pups within 65 days corresponding to 35% and 32% of inhibition respectively in the higher endosulfan dose (1.5 mg/kg).
Helena Cristina, Silva de Assis +6 more
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