Results 51 to 60 of about 1,615,506 (361)

Pharmacokinetic Interaction of Green Rooibos Extract With Atorvastatin and Metformin in Rats

Frontiers in Pharmacology, 2019
An aspalathin-rich green rooibos extract (Afriplex GRT™) has demonstrated anti-diabetic and hypolipidemic properties, while also moderately inhibiting CYP3A4 activity, suggesting a potential for herb–drug interaction.
Oelfah Patel, Oelfah Patel, Christo J.F. Muller, Christo J.F. Muller, Christo J.F. Muller, Elizabeth Joubert, Elizabeth Joubert, Bernd Rosenkranz, Bernd Rosenkranz, Malcolm J.C. Taylor, Johan Louw, Johan Louw, Charles Awortwe, Charles Awortwe   +13 more
doaj   +1 more source

Swimming exercise increases serum irisin level and reduces body fat mass in high-fat-diet fed Wistar rats

Lipids in Health and Disease, 2016
BackgroundIt has been shown that irisin levels are reduced in skeletal muscle and plasma of obese rats; however, the effect of exercise training on irisin level remains controversial.
Yun Lu, Hongwei Li, S. Shen, Zhenhai Shen, Mingjie Xu, Cheng-Jian Yang, Feng Li, Yin-Bo Feng, Jingting Yun, Ling Wang, H. Qi   +10 more
semanticscholar   +1 more source

Interactions of Interaural Time and Level Differences in Spatial Hearing with Cochlear Implants

Advanced Science, EarlyView.
Differences in timing (ΔT) are weighted heavily compared to differences in loudness (ΔL) in binaural hearing with cochlear implants. Abstract Normally hearing humans can localize sound sources quite accurately, with minimum audible angles as small as 1°. To achieve this, these auditory pathways combine information from multiple acoustic cues, including
Sarah Buchholz, Susan Arndt, Jan W. H. Schnupp, Nicole Rosskothen‐Kuhl   +3 more
wiley   +1 more source

Histologic Effects of Carbonated Drinks on Rat Kidney

Journal of Rawalpindi Medical College, 2015
Background: To study the histologic effects of carbonated drinks on rat kidneys Methods: In this experimental animal study histological changes on rat kidney caused by chronic consumption of carbonated drinks were observed.
Ayesha Fahim
doaj  

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source

Evaluation of the cognitive, physiological, and biomarker effects of heavy metal exposure in Wistar rats [PDF]

Veterinary World
Background and Aim: Individuals exposed to heavy metals are known to experience physiological and biochemical changes, which raise questions regarding possible health effects.
Senna Mukhi, Poornima Ajay Manjrekar, Rukmini Mysore Srikantiah, Sindhu Harish, Himani Kotian, Y. Lakshmisha Rao, Anita Sherly   +6 more
doaj   +1 more source

Programmable Pentamolecular Cross‐Scale Imaging Reveals the Multiplicative Synergistic Effect of High‐Fat / High‐Salt Diet on Atherosclerosis

Advanced Science, EarlyView.
This study demonstrates multifactorial lifestyle impacts on the pathogenesis and progression of cardiovascular diseases by a nanofluorescence sensor array for detecting four redox species and protein phosphorylation levels. Through cross‐scale fluorescence imaging of rats with different diets, we revealed that compared with single dietary interventions,
Jin Li, Na Zhao, Mengmeng Lu, Ruize Zhao, Wei Zhang, Ping Li, Yue Tang, Wen Zhang, Hui Wang, Bo Tang   +9 more
wiley   +1 more source

The Protective Effect of Naringin against Bleomycin-Induced Pulmonary Fibrosis in Wistar Rats

Pulmonary Medicine, 2016
The aim of the current study was to investigate the protective effect of naringin on bleomycin-induced pulmonary fibrosis in rats. Twenty-four Wistar rats randomly divided into four groups (control, bleomycin alone, bleomycin + naringin 40, and bleomycin
N. Turgut, H. Kara, S. Elagoz, K. Deveci, H. Gungor, E. Arslanbaş   +5 more
semanticscholar   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Species specific behavioural patterns (digging and swimming) and reaction to novel objects in wild type, Wistar, Sprague-Dawley and Brown Norway rats. [PDF]

PLoS ONE, 2012
BACKGROUND: The purpose of the present study was to analyse species-specific forms of behaviour (digging and swimming) and response to novelty in laboratory rats and their wild type counterparts at a very early stage of laboratorization.
Rafał Stryjek, Klaudia Modlińska, Wojciech Pisula   +2 more
doaj   +1 more source