Results 21 to 30 of about 119,674 (242)

The Withdrawal of UN Peace Operations and State Capacity: Descriptive Trends and Research Challenges [PDF]

International Peacekeeping, 2020
While United Nations Peace Operations (UN POs) have moved away from traditional, security-focused mandates in the last generation of peace missions, most research on the effectiveness of peace miss...
Di Salvatore J., Ruggeri A.
openaire   +2 more sources

Protective Effect of Exercise on Liver Oxidative Stress, Inflammation and Histopathological Changes after Morphine Withdrawal in ‎Rats

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: The harmful effects of morphine on the liver after withdrawal syndrome are unclear. In this experiment, we investigated the effects of exercise on oxidative stress, liver inflammation, liver enzymes, and liver histology after ...
Ebrahim Abbasi, iraj salehi, Ebrahim Zarin Kalam, Kamal Ranjbar, Fatemeh Mirzaei, Alireza Komaki, Sara Soleimani Asl   +6 more
doaj  

Inestigation on withdrawal strength and moment resistance of mortise and tenon joint [PDF]

تحقیقات علوم چوب و کاغذ ایران, 2009
The influence withdrawal strength and bending moment of mortise and tenon joint is investigated. Based on vast application of this type of different length of joint, the effect of tenon lengths (20 , 30, 40, mm) and wood type (beech, alder,spruce) These ...
amir lashgari, Ahmad Jahan latibari
doaj   +1 more source

Medical education and law: withholding/withdrawing treatment from adults without capacity

Internal Medicine Journal, 2015
AbstractBackgroundLaw is increasingly involved in clinical practice, particularly at the end of life, but undergraduate and postgraduate education in this area remains unsystematic. We hypothesised that attitudes to and knowledge of the law governing withholding/withdrawing life‐sustaining treatment from adults without capacity (the WWLST law) would ...
Parker, M, Willmott, L, White, B, Williams, G, Cartwright, Colleen M   +4 more
openaire   +3 more sources

Parent Quality of Life at Two Years Following Their Child's Completion of Acute Lymphoblastic Leukemia Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Parents of children treated for acute lymphoblastic leukemia (ALL) often experience significant caregiver burden and disruption to their well‐being. While parent quality of life (QoL) during treatment is well characterized, little is known about outcomes during early survivorship.
Sara Dal Pra, Maria McCarthy, Michael Takagi, Cinzia De Luca   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Immunological monitoring of renal transplant recipients to predict acute allograft rejection following the discontinuation of tacrolimus. [PDF]

PLoS ONE, 2008
BACKGROUND: Transplant patients would benefit from reduction of immunosuppression providing that graft rejection is prevented. We have evaluated a number of immunological markers in blood of patients in whom tacrolimus was withdrawn after renal ...
Ellen Kreijveld, Hans J P M Koenen, Bram van Cranenbroek, Esther van Rijssen, Irma Joosten, Luuk B Hilbrands   +5 more
doaj   +1 more source

Effect of β-Blocker Withdrawal on Functional Capacity in Heart Failure and Preserved Ejection Fraction

Journal of the American College of Cardiology, 2021
Chronotropic incompetence has shown to be associated with a decrease in exercise capacity in heart failure with preserved ejection fraction (HFpEF), yet β-blockers are commonly used in HFpEF despite the lack of robust evidence.This study aimed to evaluate the effect of β-blocker withdrawal on peak oxygen consumption (peak Vo2) in patients with HFpEF ...
Palau, Patricia, Seller, Julia, Domínguez Mafé, Eloy, Sastre, Clara, Ramón, Jose María, De la Espriella, Rafael, Santas, Enrique, Miñana, Gema, Bodí, Vicent, Sanchis, Juan, Valle, Alfonso, Chorro, F. Javier, Llácer, Pau, Bayés‐Genís, Antoni, Núñez, Julio   +14 more
openaire   +4 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source