Results 111 to 120 of about 39,136 (290)

Transcranial Magnetic Stimulation as a Translational Biomarker in Early‐Phase Anti‐Seizure Medication Development: A Randomized, Double‐Blind, Placebo‐Controlled Study in Generalized Epilepsy

Clinical Pharmacology &Therapeutics, EarlyView.
One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba, Titia Q. Ruijs, Annika A. de Goede, Robert J. Doll, Maria Juachon, Michel J. A. M. van Putten, Geert Jan Groeneveld, Jules A. A. C. Heuberger   +7 more
wiley   +1 more source

Drugs potentially affecting the extent of airways reversibility on pulmonary function testing are frequently consumed despite guidelines

International Journal of COPD, 2013
Terry E Jones,1 AnneMarie Southcott,2 Sean Homan3 1Pharmacy Department, The Queen Elizabeth Hospital, Woodville South, SA, 2Respiratory and Sleep Medicine, Western Health, Footscray, VIC, 3Respiratory Unit, The Queen Elizabeth Hospital, Woodville South ...
Southcott A, Homan S, Jones TE
doaj  

The persistent vegetative state: legal and ethical issues [PDF]

, 1995
Recent advances in technology and medical expertise have enabled doctors to prolong the lives of many severely injured patients who only a few years ago would have died from their injuries. The prolongation of life by such measures has raised many legal,
Dobson, Rosemary
core  

The Milk Withholding Time of Salicylic Acid for Treatment of Digital Dermatitis in Dairy Cattle [PDF]

, 2020
Digital dermatitis is a top cause of lameness in dairy cattle that results in ulcerative lesions on the feet. Topical salicylic acid has been shown to provide similar efficacy to the antibiotic drugs used previously, but there is no milk withholding ...
Wirt, Kelsey Marie
core  

The Sustainability Revolution: How Generative AI Powers Ethical and Transparent Global Supply Chains

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study examines how generative artificial intelligence (GenAI) can strengthen transparency and sustainability in global supply chains. Specifically, it distinguishes between (i) GenAI‐enabled sustainability reporting (i.e., automated generation of auditable narrative disclosures from multi‐tier supply chain data) and (ii) predictive ...
Rizwan Matloob Ellahi, Jawaid Ahmed Qureshi, Muhammad Hamza Farooqui, Syed Muhammad Abbas Shah, Fizzah Ayub   +4 more
wiley   +1 more source

ASPEK BIOETIKA-MEDIKOLEGAL PENUNDAAN DAN PENGHENTIAN TERAPI BANTUAN HIDUP PADA PERAWATAN KRITIS

JKS (Jurnal Kedokteran Syiah Kuala), 2017
Abstrak. Penundaan terapi bantuan hidup adalah menunda pemberian terapi bantuan hidup baru atau lanjutan tanpa menghentikan terapi bantuan hidup yang sedang berjalan,  sedangkan penghentian terapi bantuan hidup adalah menghentikan sebagian atau semua ...
Taufik Suryadi
doaj  

Symbolic Versus Substantive ESG Practices: A Systematic Review and Integrative Framework

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT ESG reporting is widespread, but symbolic commitments do not always reflect substantive practices. This study conducts a systematic literature review of 62 empirical articles published between 2021 and 2025 to synthesize the main determinants and consequences of this disclosure–performance misalignment in ESG reporting (commonly referred to as
Cristina Alexandrina Ştefănescu, Andra Larisa Suciu   +1 more
wiley   +1 more source

N‐SDM 2.0: a reengineered software with extended features for nested species distribution modelling

Ecography, EarlyView.
Species distribution models (SDMs) are central tools for predicting and forecasting how species respond to environmental changes, yet their reliability depends on accurately capturing ecological processes across spatial scales while accounting for uneven data availability and resolution.
Antoine Adde, Teresa Goicolea, Antoine Guisan, Florian Altermatt   +3 more
wiley   +1 more source

Challenges in Implementing European Regulation on Water Reuse for Sustainable Agriculture

Environmental Policy and Governance, EarlyView.
ABSTRACT The Regulation (EU) 2020/741 on minimum requirements for water reuse is a key policy for sustainable water management under growing water scarcity in Europe. This paper examines expert perspectives on the challenges involved in implementing EU regulation for water reuse in agriculture, aiming to broaden existing research, which is largely ...
Patricia Allgaier, Roberta Maffettone, Kevin Grecksch   +2 more
wiley   +1 more source

Implementation of guideline‐recommended medical therapy for patients with heart failure in Europe

ESC Heart Failure, Volume 12, Issue 2, Page 790-798, April 2025.
Abstract Physicians' adherence to guideline‐recommended heart failure (HF) treatment remains suboptimal, especially regarding the target doses. In particular, there is evidence that non‐cardiologists are less compliant with HF guideline recommendations. This is likely to have a detrimental impact on patients' survival, readmissions and quality of life.
Maurizio Volterrani, Petar Seferovic, Gianluigi Savarese, Ilaria Spoletini, Egidio Imbalzano, Antoni Bayes‐Genis, Ewa Jankowska, Michele Senni, Marco Metra, Ovidiu Chioncel, Andrew J. S. Coats, Giuseppe M. C. Rosano   +11 more
wiley   +1 more source