Results 181 to 190 of about 1,078,394 (297)

Orthopaedic Trauma Management in the Jehovah's Witness Population. [PDF]

J Am Acad Orthop Surg Glob Res Rev
Saxena TA, Massey PA, Chauvin B.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

See it … Speak it… Write it…. Change it: On the Introduction of a Canadian Journal Grounded in Critical Nursing Discourse

Witness, 2019
Cheryl van Daalen-smith, Simon Adam
doaj   +1 more source

Living the Charisms of the Sovereign Military Order of Malta in Modern Medicine:Catholic Healthcare Professionals Enact Malta's Principles in Routine Patient Care. [PDF]

Linacre Q
Kozak R.
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Age-Treatment Interactions in Out-of-Hospital Cardiac Arrest: A Nationwide Registry Analysis. [PDF]

J Clin Med
Kiss B, Pál-Jakab Á, Nagy B, Koós G, Csató G, Pápai G, Merkely B, Zima E.   +7 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Feasibility of public CPR training kiosks to increase bystander resuscitation: a Monte Carlo simulation study. [PDF]

Resusc Plus
Ohle R, Savage DW, Roy D, Yadav K, Chhabra S, McIsaac S.   +5 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

SelectVote Byzantine Fault Tolerance for Evidence Custody: Virtual Voting Consensus with Environmental Compensation. [PDF]

Sensors (Basel)
Onyeashie BI, Leimich P, McKeown S, Russell G.   +3 more
europepmc   +1 more source