Results 41 to 50 of about 11,273 (222)

Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates

Chemistry – A European Journal, EarlyView.
The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma, Peter A. C. Wing, Wojtek Treyde, Shyam Basak, Simeon D. Draganov, Taylah Andrews‐Clark, Eidarus Salah, Petra Lukacik, Claire Strain‐Damerell, Adán Pinto‐Fernández, Martin A. Walsh, Fernanda Duarte, Christopher J. Schofield, Lennart Brewitz   +13 more
wiley   +1 more source

Aktivasi Zeolit Alam Asal Bayah dengan Asam dan Basa sebagai Aditif Campuran Beraspal Hangat (Warm Mixed Asphalt)

Jurnal Teknik Sipil, 2018
Warm Mix Asphalt (WMA) adalah campuran beraspal yang diproduksi pada suhu 20-40°C lebih rendah dari HMA. Zeolit merupakan salah satu bahan tambah WMA dengan memanfaatkan kemampuan zeolite membawa air dan melepaskannya pada suhu tinggi sehingga terjadi ...
Leo Sentosa, Bambang Sugeng Subagio, Harmein Rahman, R. Anwar Yamin   +3 more
doaj   +1 more source

Toward Objective Anal Cancer Screening: From Swab‐Based Genome‐Wide Methylation Marker Discovery to Novel Test Development

International Journal of Cancer, EarlyView.
ABSTRACT Anal high‐grade squamous intraepithelial lesions (HSIL:AIN2/3) are precursors to anal cancer, and early detection and treatment through screening is crucial for effective cancer prevention. Current guidelines recommend anal swab‐based screening and highlight the need for objective biomarkers to improve risk stratification.
Kirsten Rozemeijer, Jürgen Claesen, Fernando Dias Gonçalves Lima, Albertus T. Hesselink, Phoebe Klingers, Timo ter Braak, Yara van den Burgt, Chris J. L. M. Meijer, Jan M. Prins, Henry J. C. de Vries, Mark A. van de Wiel, Renske D. M. Steenbergen   +11 more
wiley   +1 more source

An efficient bio-inspired algorithm based on humpback whale migration for constrained engineering optimization

Results in Engineering
This work presents the Whale migrating Algorithm (WMA), an innovative bio-inspired metaheuristic optimization method based on the collaborative migrating behavior of humpback whales.
Mojtaba Ghasemi, Mohamed Deriche, Pavel Trojovský, Zulkefli Mansor, Mohsen Zare, Eva Trojovská, Laith Abualigah, Absalom E. Ezugwu, Soleiman kadkhoda Mohammadi   +8 more
doaj   +1 more source

Clustering of Cerebral Microbleeds in Cerebral Amyloid Angiopathy: A Flow Territory‐Based Analysis

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Cerebral microbleeds (CMBs) are a key imaging marker of cerebral amyloid angiopathy (CAA), but their individual spatial distribution and potential clustering remain poorly understood. Purpose This study assessed whether CMBs exhibit patient‐specific, flow territory‐based clustering in sporadic (sCAA) and Dutch‐type hereditary CAA (D‐
Manon R. Schipper, Reinier G. J. van der Zwet, Jelle J. Goeman, Thijs W. van Harten, Emma A. Koemans, Marieke J. H. Wermer, Marianne A. A. van Walderveen, Matthias J. P. van Osch   +7 more
wiley   +1 more source

The impact of the first COVID-19 lockdown on weight management practices in UK adults: A self-regulation perspective

Health Psychology Open, 2023
This study aimed to identify the impact of the first UK COVID-19 lockdown on individuals’ weight management attempts (WMA). A self-regulation theoretical framework was used to identify predictors of continuing with a WMA, and weight change during the ...
Denisa Genes, Fuschia M Sirois, Nicola J Buckland   +2 more
doaj   +1 more source

Increased radiolucency on conventional radiographs around tibial components does not imply more load‐induced displacement of a total knee arthroplasty

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose After total knee arthroplasty (TKA), radiolucent lines on routine conventional radiographs are commonly interpreted as impaired tibial component fixation, although their relation to implant motion remains unclear. This necessitates a comparison with measured component displacement.
Chiel Klein, George S. Buijs, Maaike A. ter Wee, Milo J. K. Mokkenstorm, Johannes G. G. Dobbe, Matthias U. Schafroth, Geert J. Streekstra, Leendert Blankevoort, Arthur J. Kievit   +8 more
wiley   +1 more source

The Laboratory Characterization of a Warm Asphalt Mixture Incorporating Reclaimed Asphalt Pavement

Infrastructures
Nowadays, the most widespread solutions to increase the sustainability of bituminous mixes deal with the recycling of reclaimed asphalt pavement (RAP) and the use of warm mix asphalt (WMA).
Edoardo Bocci, Carlo Carpani
doaj   +1 more source

Moisture Damage of Warm Mix Asphalt Concrete

Journal of Engineering, 2019
Implementation of Warm Mix Asphalt concrete (WMA) is getting global acceptance due to the restrictions for protecting the environment and the requirements to reduce fuel consumption.
Zain alabidine Nihad Abdul Mahdi, Saad I. Sarsam   +1 more
doaj   +1 more source

Assembling Engagement With Autonomy and Language ‐ A Neuroscientific Case Study With Digital Companions

Psychology &Marketing, EarlyView.
ABSTRACT This study addresses the need to understand human engagement with empathic Generative Artificial Intelligence (GenAI) digital companions (DC), as these systems increasingly fulfil social and emotional roles in daily life. Motivated by the rapid adoption of DC technologies and their potential to reshape human–AI relationships, the study applies
Aitor Ezker‐Galech, Raquel Chocarro, Mónica Cortiñas, Álvaro Saavedra   +3 more
wiley   +1 more source