Results 71 to 80 of about 74,022 (242)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Patient centred care and considerations

, 2020
This chapter shares the findings of a large scale research project into patient centred care in diagnostic ...
Hyde, E.
core  

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Exploring women's experiences with cultural practices during pregnancy and birth in Keiyo, Kenya: A phenomenological study

International Journal of Africa Nursing Sciences
Childbearing is associated with memories from experiences encountered during the childbearing journey. Besides the physiological and biological nature of pregnancy and birth, culture influences experiences and the meanings of surroundings. Care providers
Teckla Kemboi Ngotie, Doreen K.M. Kaura, Bob Mash   +2 more
doaj   +1 more source

Value based maternal and newborn care requires alignment of adequate resources with high value activities

BMC Pregnancy and Childbirth, 2019
Background Evidence based practice has been associated with better quality of care in many situations, but it has not been able to address increasing need and demand in healthcare globally and stagnant or decreasing healthcare resources.
Ank De Jonge, Soo Downe, Lesley Page, Declan Devane, Helena Lindgren, Joke Klinkert, Muir Gray, Anant Jani   +7 more
doaj   +1 more source

Health-economic evaluations of person-centred care [PDF]

, 2020
Person-centred care aims at making the individual partake in the healthcare decisionmaking and at supporting individual health management. This stands in contrast to usual care, which typically has more focus on the particular disease at hand, rather ...
Pirhonen, Laura
core   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Support provided by midwives to women during labour in a public hospital, Limpopo Province, South Africa: a participant observation study

BMC Pregnancy and Childbirth, 2018
Background Physical presence during labour offer women opportunity of having positive childbirth experiences as well as childbirth outcomes. The study aimed to determine what support provided by midwives during intrapartum care at a public hospital in ...
Maria S. Maputle
doaj   +1 more source

Family-centred care at end of life in critical care: A retrospective descriptive study

, 2022
Background: A family-centred approach to care can aid family coping at the end of life in critical care. Yet little is known about how families’ preferences for involvement in care planning and decision-making, are assessed and supported. Aim: To explore
Poon, P, Hutchinson, AM, Bloomer, MJ, Runacres, F   +3 more
core   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source