Results 41 to 50 of about 796,919 (268)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Female foul language and foul female agents in pre-modern Portugal

open access: yesLer História, 2017
Through the examination of a number of archival sources and legislation from the late fourteenth to the eighteenth century, this study looks at the phenomenon of the female scold in pre-modern Portugal.
Darlene Abreu-Ferreira
doaj   +1 more source

Cinderellas in Breeches [PDF]

open access: yes, 2005
Selvedge is a specialist textiles magazine with an international circulation. An article which documents the biography of a pair of breeches issued as part of the uniform of the Women’s Land Army during the Second World War.
de la Haye, Amy
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Spain’s Living Daughters

open access: yesThe Journal of the Sylvia Townsend Warner Society, 2023
Warner’s article describes in detail the harsh economic conditions and powerful social restrictions in women’s lives in rural Spain. She notes that the marriage rites of the Spanish Church describe women as the property of their husbands.
doaj   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

A brief history of women’s history [PDF]

open access: yes, 2016
“Where are the women?” When Cynthia Enloe posed this question in 1989, she was thinking about the world of international politics. But the question has also been a driving force for a number of historians who have sought to move beyond the narratives of “
Bourbonnais, Nicole
core  

Do Successive Preterm Births Increase the Risk of Postpartum Depressive Symptoms? [PDF]

open access: yes, 2017
Background. Postpartum depression and preterm birth (PTB) are major problems affecting women’s health. PTB has been associated with increased risk of postpartum depressive symptoms (PDS). However, it is unclear if PTB in women with a prior history of PTB
Ihongbe, Timothy O., Masho, Saba W.
core   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

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