Results 71 to 80 of about 792,696 (271)
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
"This is a Business Transaction, fundamentally": Surrogate Motherhood in Meera Syal's The House of Hidden Mothers [PDF]
, 2018 Meera Syal’s latest novel, The House of Hidden Mothers (2015), depicts the current practice of international surrogacy and raises questions about this form of reproduction which commodifies babies and constructs poor women’s bodies in India and elsewhere
Pérez Fernández, Irene
core
ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
FEBS Open Bio, EarlyView.Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
wiley +1 more source
TMC4 localizes to multiple taste cell types in the mouse taste papillae
FEBS Open Bio, EarlyView.Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source
Contree, 2015 Established as an organisation with the aim to influence all aspects of Afrikaner life, the Ossewa-Brandwag (OB) made an impact on the lives of thousands of Afrikaners between 1939 and 1954.
Charl Blignaut
doaj +1 more source
Connecting Women's Histories: the local and the global [PDF]
, 2016 The articles in this Special Issue are drawn from some of the contributions to a conference held at Sheffield Hallam University, UK, from 29 August to 1 September 2013 titled ‘Women’s Histories: the local and the global’.
Bush, Barbara, Purvis, June
core +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Women's Studies in Poland [PDF]
, 2001 Athena: Advanced Thematic Network in Activities in Women's Studies in Europe. Report from ATHENA panel of experts 1.a.: A Cross-European, Comparative Study of Degrees, Qualifications and Professional Outlets of Women's/Gender/Feminist Studies.
Oleksy, Elżbieta H.
core
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source