Results 71 to 80 of about 7,975,658 (293)
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
Contree, 2015 Established as an organisation with the aim to influence all aspects of Afrikaner life, the Ossewa-Brandwag (OB) made an impact on the lives of thousands of Afrikaners between 1939 and 1954.
Charl Blignaut
doaj +1 more source
History of Key Events in Women’s Health Care
, 2016 In 1973, ninety-three percent of all American doctors were men (Ehrenreich and English). Gender based inequity permeates all spheres of women’s health care from employment to access to treatment to biologically-based myths of male superiority, yet women ...
Chambliss, Zoё M.
core
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
FEBS Open Bio, EarlyView.Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
wiley +1 more source
TMC4 localizes to multiple taste cell types in the mouse taste papillae
FEBS Open Bio, EarlyView.Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
‘You do manage it so well that I cannot do better’: the working life of Elizabeth Jeake of Rye (1667-1736) [PDF]
, 2018 This is an Accepted Manuscript of an article published by Taylor & Francis in Women's History Review on 27 March 2018, available online at: https://doi.org/10.1080/09612025.2018.145556.
Murphy, Anne L.
core +3 more sources
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Caught between dialogue and diktat – The International Midwives Union 1933–1945
Theatrum Historiae, 2020 In 1919 the International Midwives Union (IMU) was founded in Belgium. For two decades it was dominated by Professor Frans Daels from Belgium (1881-1974), a gynaecologist from Gent. Its main assembly was the bi-annual international congress, e.g.
Anja Katharina Peters
doaj