Results 41 to 50 of about 98,440 (229)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Podcasting Feminism: The Multimodality of Women’s Writing and Literary-Historical Studies

KULA
Created by a team of literary scholars, students, and a librarian, Orlando: A Podcast on Women’s Writing comprises twelve informal interviews that synthesize and share scholarly work on women’s writing from medieval times to the present, with capacious ...
Christie Hurrell, Kathryn Holland, Karen Bourrier, Jessica Khuu   +3 more
doaj   +1 more source

Radical Reform and the Shock of the Past in Mary Robinson’s Vancenza [PDF]

Litteraria Pragensia
Mary Robinson’s first novel, Vancenza (1792), charted a new path for politically liberal women writers. Robinson used her pre-existing reputation as an actress, mistress and established poet to carve out a space in which she could write and publish ...
Eleanor Franzén
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Polish and Czech “literary reciprocity” in the second half of the 19th century: Eliza Orzeszkowa’s reception by the Czechs and Karolina Světlá’s reception by the Poles

Poznańskie Studia Slawistyczne, 2012
The aim of the article is to describe the extraordinarily animated and extensive relationships between Polish and Czech literature in the second half of the 19th century.
Corinne Fournier Kiss
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Representasi Perempuan dalam Novel Selaput Biru Karya Laksmi Pamuntjak: Kajian Ginokritik serta Implikasi pada Nilai Moral

Jentera: Jurnal Kajian Sastra
This study is motivated by the representation of women in Selaput Biru, a novel by Laksmi Pamuntjak, examined through a gynocritical perspective and its implications for moral values, demonstrating that women can enact resistance through women’s writing ...
Amelia Susanti, Maman Suryaman, Esti Swatika Sari   +2 more
doaj   +1 more source

Ambiguity of Interpretation: the Gender-Conscious Attitudes in the Dissident Works of the Czech Writer Lenka Procházková

Poznańskie Studia Slawistyczne, 2016
This paper explores the presence of gender-conscious attitudes in the works of the Czech author Lenka Procházková (born 1951), a member of the dissident movement during the communist regime.
Ursula Stohler
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source