Results 31 to 40 of about 98,440 (229)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Women’s ‘Defence-Narrative’ and its Role in the Formation of the Novel
Sanglap: Journal of Literary and Cultural Inquiry, 2021 The practice of women defending themselves in writing, which is often called the “women’s defence-narrative,” is a tradition that emerged in the late medieval period and continued as a dominant strain in women’s writing through the early modern period ...
Subhasish Guha
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
The Banality of Violence in A. L. Kennedy’s Early Short Stories
Acta Neophilologica, 2020 The present paper adapts Hannah Arendt’s concept of the banality of evil to illustrate the banality of a specific manifestation of evil, which is violence, as it is presented in the early short stories of A. L. Kennedy.
Ema Jelínková
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Women in Islamic Historiography and History
Jurnal Indo-Islamika, 2023 This article aims to reveal the rareness of historical writing that elevated the female figure as the main character. This gives rise to the assumptions that women are not much involved in history.
Didin Saepudin, Nabila Himmatina Zahra
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Trivial or Commendable? : Women’s Writing, Popular Culture, and Chick Lit [PDF]
452ºF, 2010 There are a number of similarities between popular culture and women's writing: both have been dismissed as trivial and worthless, have traditionally received little respect from critics, and have been scorned because of theis apparently "low-brow ...
Ryan, Mary
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source