Results 91 to 100 of about 179,209 (261)
Forskolin induces FXR expression and enhances maturation of iPSC-derived hepatocyte-like cells
Frontiers in Cell and Developmental BiologyThe generation of iPSC-derived hepatocyte-like cells (HLCs) is a powerful tool for studying liver diseases, their therapy as well as drug development.
Christiane Loerch +6 more
doaj +1 more source
Advanced Science, EarlyView.IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang +15 more
wiley +1 more source
Preventing soft skill decay among early-career women in STEM during COVID-19: Evidence from a longitudinal intervention. [PDF]
Proc Natl Acad Sci U S A, 2022 Melin JL, Correll SJ.
europepmc +1 more source
Advanced Science, EarlyView.This study revealed how the osteoblastic microenvironment determines the fate of cancer cells disseminated in bone, with a focus on whether they colonize, reside in quiescence, or reactivate from dormancy. Targeting integrin signaling may offer promising strategies for preventing quiescent cancer cells reactivation and bone colonization.
Hong‐Li Wang +7 more
wiley +1 more source
Factors Facilitating and Impeding Women’s Retention in Math-Intensive STEM Fields
Вопросы образованияIncreasingly, there has been a notable lack of female representation in math-intensive STEM fields, such as engineering, geosciences, mathematics, computer science, and physics.
Ainur Almukhambetova +2 more
doaj +1 more source
Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis
Advanced Science, EarlyView.ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai +15 more
wiley +1 more source
Advanced Science, EarlyView.Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong +6 more
wiley +1 more source
Advancing women in STEM: institutional transformation [PDF]
The Lancet, 2019 Susan M, Shaw +10 more
openaire +2 more sources
Advanced Science, EarlyView.A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li +22 more
wiley +1 more source