Results 101 to 110 of about 115,635,683 (250)

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

W-STEM Process Mapping Template

, 2019
Template to collect the process associated to the attraction, access, guidance and retention of students into STEM programs.
W-STEM Consortium, W-STEM Consortium (6643448)   +1 more
core   +1 more source

WOMEN and STEM

, 2011
This article describes a Faculty Speaker Series organized by Jenessa Shapiro, Assistant Professor in the Psychology Department at UCLA, in Conjunction with UCLA's Center for the Study of Women. The Speaker Series has invited scholars to discuss the issues surrounding women and STEM.
openaire   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Editorial: Women in regulatory toxicology: 2021

Frontiers in Toxicology, 2022
Marlene Ågerstrand, Anna Beronius, Marion Junghans, Olwenn Martin   +3 more
doaj   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Honouring the women of STEM in Medway

This article provides an opportunity for me to draw comparisons between Black women in STEM and women from other cultural backgrounds and races, exploring whether they too face similar challenges regarding the intersectional factors of gender, race, and ...
Masumi, M.
core  

Conferència: “Women in STEM”

, 2019
Vídeo de la conferència “Women in STEM”, a càrrec de l’enginyera Elisabeth Rasekoala, que va tenir lloc el 13 de juny, a l’Auditori de l’edifici Vèrtex. El 13 de juny passat, l'enginyera Elisabeth Rasekoala va impartir la conferència "Women in STEM" a

core   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

W-STEM Partnership

, 2019
Description of the W-STEM ...
W-STEM Consortium, W-STEM Consortium (6643448)   +1 more
core   +1 more source