Results 51 to 60 of about 1,429,014 (308)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Dehydration regulates structural reorganization of dynamic hydrogels

Nature Communications
The dehydration process is widely recognized as a significant phenomenon in nature. Hydrogels, which are important functional materials with high water content and crosslinked networks, encounter the issue of dehydration in their practical applications ...
Dan Xu, Xintong Meng, Siyuan Liu, Jade Poisson, Philipp Vana, Kai Zhang   +5 more
doaj   +1 more source

Hyperspectral imaging applied to end-of-life (EOL) concrete recycling [PDF]

, 2015
The recovery of materials from DW is an important target of the recycling industry and it is important to know which materials are presents in order to set up efficient sorting and/or quality control actions.
Bonifazi, Giuseppe, Palmieri, Roberta, Serranti, Silvia   +2 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Green Synthesis of Hierarchical Metal–Organic Framework/Wood Functional Composites with Superior Mechanical Properties

Advanced Science, 2020
The applicability of advanced composite materials with hierarchical structure that conjugate metal–organic frameworks (MOFs) with macroporous materials is commonly limited by their inferior mechanical properties.
Kunkun Tu, Begoña Puértolas, Maria Adobes‐Vidal, Yaru Wang, Jianguo Sun, Jacqueline Traber, Ingo Burgert, Javier Pérez‐Ramírez, Tobias Keplinger   +8 more
doaj   +1 more source

Potential of X-ray computed tomography for 3D anatomical analysis and microdensitometrical assessment in wood research with focus on wood modification [PDF]

, 2013
Studying structure and chemistry of wood and wood-based materials is the backbone of all wood research and many techniques are at hand to do so. A very valuable modality is X-ray computed tomography (CT), able to non-destructively probe the three ...
Andersons, Bruno, Biziks, Vladimir, Boone, Matthieu, Brabant, Loes, De Witte, Yoni, Dierick, Manuel, Mahnert, Karl-Christian, Masschaele, Bert, Militz, Holger, Van Acker, Joris, Van den Bulcke, Jan, Van Hoorebeke, Luc, Van Loo, Denis, Vlassenbroeck, Jelle   +13 more
core   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Technique for in-place welding of aluminum backed up by a combustible material [PDF]

, 1971
Welding external aluminum jacket, tightly wrapped around inner layer of wood composition fiberboard, in oxygen free environment prevents combustion and subsequent damage to underlying fiberboard.
Spagnuolo, A. C.
core   +1 more source

Light-weight wood-magnesium oxychloride cement composite building products made by extrusion [PDF]

, 2012
This is the post-print version of the final paper published in Construction and Building Materials. The published article is available from the link below.
Li, Z, Zhou, X
core   +2 more sources

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source