Results 41 to 50 of about 987,359 (249)

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Sand flies of Nicaragua: a checklist and reports of new collections

open access: yesMemorias do Instituto Oswaldo Cruz, 2010
Sand flies within the genus Lutzomyia serve as the vectors for all species of the protozoan parasite Leishmania in the New World. In this paper, we present a summary of the 29 species of Lutzomyia and one of Brumptomyia previously reported for Nicaragua ...
Russell W Raymond   +2 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

An Exploration on HIV/AIDS Funding in South Africa

open access: yesSAGE Open, 2017
The human immunodeficiency virus (HIV), which leads to acquired immunodeficiency syndrome (AIDS) epidemic, is a global concern in which billions of dollars have been poured into various countries for the prevention and management of this life threatening
Anida A. Duarte, John W. Hancock
doaj   +1 more source

The Limits of Grief in Augustine of Hippo’s Sermones 172-173 and Sermo 396

open access: yesVox Patrum, 2021
This contribution explores select sermons of Augustine relating to the pastoral and existential phenomena of grief and human mortality (ss. 172-173 and s. 396).
Joseph L. Grabau
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Hilary Word [PDF]

open access: yes, 2020
Originally from Jackson, Mississippi, Hilary earned her undergraduate degree in history from Tougaloo College. As a life-long fan of speculative fiction, mythology, and folklore, Word has always been fascinated with the concept of the real versus the ...
Word, Hilary, Morales, Andrea
core   +1 more source

Thai word segmentation for visualization of Thai Web sites [PDF]

open access: yes, 2011
Information overload is a problem in the Information Age and Information visualization is an approach to provide an overview of the content of a web site. Tag cloud is one of the ways to represent information as an image of a group of words.
Wigrai Thanadechteemapat   +3 more
core   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

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