Results 51 to 60 of about 1,189,581 (305)
Head-Mounted Display-Based Microscopic Imaging System with Customizable Field Size and Viewpoint
Sensors, 2020 In recent years, the use of microinjections has increased in life science and biotechnology fields; specific examples include artificial insemination and gene manipulation.
Tadayoshi Aoyama +3 more
doaj +1 more source
Palaearctic origin of Leishmania [PDF]
Memorias do Instituto Oswaldo Cruz, 2000 The hypothesis of a Palaearctic origin of Leishmania in the early Cenozoic, dispersal to the Nearctic in the late Eocene and to the Neotropical in the Pliocene is presented. It is further hypothesized that murid rodents and their immediate ancestors have
Sara F Kerr
doaj +1 more source
The Limits of Grief in Augustine of Hippo’s Sermones 172-173 and Sermo 396
Vox Patrum, 2021 This contribution explores select sermons of Augustine relating to the pastoral and existential phenomena of grief and human mortality (ss. 172-173 and s. 396).
Joseph L. Grabau
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Going over the wall: insights into the illegal production of jaguar products in a Bolivian prison
OryxAs the largest felid in the Americas, the jaguar Panthera onca has both ecological and cultural significance in Bolivia. Yet jaguar populations are declining because of multiple pervasive anthropogenic pressures, including domestic and international ...
Angie Elwin +3 more
doaj +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Acoustic-phonetic cues to word boundary location: Evidence from word spotting. [PDF]
, 1999 This research examined acoustic-phonetic cues to word boundary location in French consonant clusters, and assessed their use in on-line lexical segmentation.
Dumay, Nicolas +4 more
core
Human Vaccines & ImmunotherapeuticsHuman papillomavirus (HPV)-associated cancers represent a substantial public health burden. This study analyzed the national burden of hospitalization and mortality from HPV-associated cancers in Brazil between 2011 and 2019.
Cintia Irene Parellada +5 more
doaj +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source