Results 191 to 200 of about 370,495 (283)

Refining Detection of Subclinical Epileptiform Activity in Alzheimer's Disease: A Case–Control Study and Call for a Consensus

open access: yesAnnals of Neurology, EarlyView.
Objective Sleep‐predominant network hyperexcitability is increasingly recognized as a potential disease‐accelerating comorbidity in Alzheimer's disease (AD). However, its prevalence and risk‐factors remain debated, largely due to cohort‐specific and methodological differences across studies.
Anna B. Szabo   +14 more
wiley   +1 more source

When Does Alzheimer's Disease Start? Plasma Aβ42/40 Assays Show Steep Changes at Aβ‐PET Centiloid 15, Mean Age of 66 Years

open access: yesAnnals of Neurology, EarlyView.
Objective Sporadic late‐onset Alzheimer's disease (AD) is characterized by a long pre‐clinical phase where amyloid‐beta (Aβ) and tau begin to accumulate in the brain. The primary objective was to determine the age at which AD starts by finding the average population age when both positron emission tomography (PET) Aβ (Aβ‐PET) and plasma Aβ42/40 become ...
Rodrigo Cánovas   +29 more
wiley   +1 more source

Neural basis of linguistic factors involved in thought: an fMRI study with native signers. [PDF]

open access: yesFront Psychol
Hino R   +5 more
europepmc   +1 more source

Understanding Neurodegenerative Diseases From the −Omics Perspective: Lessons Learnt

open access: yesAnnals of Neurology, EarlyView.
As the population ages, certain neurodegenerative diseases (NDs) are becoming a major health issue. For this reason, this review will focus on the most common ND with onset after 65 years old; Alzheimer's disease, Parkinson's disease, Lewy body dementia, and frontotemporal dementia.
Laura Ibanez   +5 more
wiley   +1 more source

From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin‐Like Proteins

open access: yesAngewandte Chemie International Edition, EarlyView.
A large variety of chemistry‐based ubiquitin probes have been developed. ABSTRACT Ubiquitin (Ub) and ubiquitin‐like proteins (Ubls) orchestrate diverse cellular processes through reversible post‐translational modification of target proteins. Their conjugation is governed by a cascade of E1 activating, E2 conjugating, and E3 ligating enzymes, while ...
Saibal Chanda, Wenshe Ray Liu
wiley   +1 more source

The Impact of Organic Constituents in Coal Chemical Wastewater on Additive Adsorption at the Coal Surface: Experimental Investigation and Molecular Dynamics Simulation

open access: yesAsia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Direct preparation of coal–water slurry using coal chemical wastewater represents an economical and feasible approach for wastewater resource utilization. Unlike clean water, however, the complex organic components in wastewater may exert adverse effects on slurry properties.
Yi Xiang   +6 more
wiley   +1 more source

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