Results 41 to 50 of about 107,303 (245)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Tagungsbericht: „Perspektiven der Movierungsforschung“ (8.–10. Oktober 2024; Universität Luxemburg)
Zeitschrift für WortbildungVom 8. bis zum 10. Oktober 2024 fand an der Universität Luxemburg am Campus Belval die Tagung „Perspektiven der Movierungsforschung“ statt, die von Caroline Döhmer (Université du Luxembourg) und Alexander Werth (Universität Passau) organisiert wurde.
Melissa Mujkić
doaj +1 more source
Portuguese Word-formation in Textbooks
Entrepalavras: Revista de Linguística do Departamento de Letras Vernáculas da Universidade Federal do Ceará, 2016 This paper results from the research project “O léxico no livro didático”, that has been developed since 2010, at the Language Institute of Universidade Federal da Bahia, based on the works of Irandé Antunes (2012), Carlos Alexandre Gonçalves (2007 ...
Alba Valéria Tinoco Alves Silva
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Word-formation features of the Kazan Gospel of the 14th century: Nominal derivation
Ученые записки Казанского университета: Серия Гуманитарные науки, 2018 The nominal word formation in the text of the Kazan Gospel of the 14th century relating to the lectionaries of the Mstislav type has been analyzed. The study aims to clarify the available data on this issue, to add to the description of the lexical and ...
N.G. Nikolaeva
doaj
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Вестник Кемеровского государственного университета, 2013 This article deals with problems of word formation in the contemporary Chinese language, particularly the formation of technical loanwords. A review of the works on types of loanwords is presented in the article.
N. V. Torchakova
doaj
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source