Results 51 to 60 of about 4,989,172 (293)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Tagungsbericht: „Perspektiven der Movierungsforschung“ (8.–10. Oktober 2024; Universität Luxemburg)

Zeitschrift für Wortbildung
Vom 8. bis zum 10. Oktober 2024 fand an der Universität Luxemburg am Campus Belval die Tagung „Perspektiven der Movierungsforschung“ statt, die von Caroline Döhmer (Université du Luxembourg) und Alexander Werth (Universität Passau) organisiert wurde.
Melissa Mujkić
doaj   +1 more source

MORPHOLOGICAL PRODUCTIVITY OF ADJECTIVE-FORMING PREFIXES IN ENGLISH AT THE LEVEL OF WORD-FORMATION RULES

Filolog, 2023
This paper studies the morphological productivity of adjective-forming prefixes at the level of word-formation rules. The productivity at the aforementioned level is the union of the productivity at the level of word-formation types and morphological ...
Maja M. Žarković Mccray
doaj   +1 more source

Data and Code Accompanying the Study "Developing an annotation framework for word formation processes in comparative linguistics"

, 2020
Cite the source of the dataset as: Schweikhard, N. E. and List, J.-M. (2020): Developing an annotation framework for word formation processes in comparative linguistics. SKASE Journal of Theoretical Linguistics.
Nathanael E. Schweikhard, Johann-Mattis List   +1 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Part-Of-Speech and Semantic-Class Preferences for Certain Word-Formation Processes: Wichi (Mataguayan)

, 2016
This chapter analyzes the differences in proportion and distribution of word-formation processes within the vocabulary of Wichi (Mataguayan). From the analysis of two quantitatively and qualitatively representative Wichi vocabularies, it is shown that ...
Nercesian, Verónica
core   +1 more source

Portuguese Word-formation in Textbooks

Entrepalavras: Revista de Linguística do Departamento de Letras Vernáculas da Universidade Federal do Ceará, 2016
This paper results from the research project “O léxico no livro didático”, that has been developed since 2010, at the Language Institute of Universidade Federal da Bahia, based on the works of Irandé Antunes (2012), Carlos Alexandre Gonçalves (2007 ...
Alba Valéria Tinoco Alves Silva
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Verbal word-formation with complex pre-element structures. Synchronic and diachronic aspects

, 2019
This paper deals with complex prefix-particle structures like aberkennen in German. First, it presents a scheme to analyse these double complex words from a synchronic point of view.
Albers, Marius
core   +1 more source