Results 51 to 60 of about 138,755 (259)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Applicability of the Compensatory Encoding Model in Foreign Language Reading: An Investigation with Chinese College English Language Learners

Frontiers in Psychology, 2017
While some first language (L1) reading models suggest that inefficient word recognition and small working memory tend to inhibit higher-level comprehension processes; the Compensatory Encoding Model maintains that slow word recognition and small working ...
Feifei Han
doaj   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Word Wars: The Role of Form and Semantic Encoding in Implicit and Explicit Recognition of Nouns and Verbs

Psychology of Language and Communication
Encoding word form and semantic information is critical for integrating new words into the lexicon. Factors like encoding context and word class impact memory traces and, thus, recognition of new words.
Pankonin Ashlie Hope, Schneider Julie M., Abel Alyson D.   +2 more
doaj   +1 more source

Diffusion-Enhanced NAT–BART Vision Language Transformer for Unified Urdu Word Recognition

IEEE Access
Handwritten Urdu text recognition remains a very challenging problem due to the cursive and complex nature of the Nastaliq script. Each writer has a unique style, and there is a severe lack of large, well-labeled datasets. These challenges make Urdu text
Wahid Hussain, Shahbaz Hassan, Isma Ul Hassan, Ahmad Raza Shahid, Asif Naeem, Muhammad Usman Yaseen, Nouman Ashraf   +6 more
doaj   +1 more source

Combining Part-of-Speech Tags and Self-Attention Mechanism for Simile Recognition

IEEE Access, 2019
Simile recognition is to find simile sentences and extract the tenor and vehicle from these sentences. Previous works illustrate that tenors and vehicles are typically noun phrases. A word may have different part-of-speech (POS) labels (e.g., adjectives,
Pengfei Zhang, Yi Cai, Junying Chen, Wenhao Chen, Hengjie Song   +4 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Effects of word length, contextual support, and prior second language proficiency on the learning of technical words in a second language.

PLoS ONE
Second language (L2) learners often struggle with learning technical words in a new discipline. Previous studies suggested that word length and context may differentially affect orthographic and semantic acquisition during initial L2 word learning.
Jie Wang, Yen Na Yum
doaj   +1 more source