Results 81 to 90 of about 3,199,150 (263)
Policies for an Ageing Workforce Work-life balance, working conditions and equal opportunities 2019 [PDF]
, 2019 At a time of rapid population ageing, a key means of sustaining current welfare states is to extend the length of working lives. In 2050, the share of people over the age of 75 years will be the same as the share over 65 years today.
Anderson, Robert +18 more
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Helping families: childcare, early education and the work-life balance [PDF]
, 2005 Since Labour came to power in May 1997, there have been substantial increases in spending aimed at helping families with formal childcare, early education and the work-life balance.
Brewer, M., Crawford, C., Dearden, L.
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Work Life Balance- What Balance?
Frontiers in Pediatrics, 2016 Tricia Shinelle Alleyne
doaj +1 more source
Traditional vs. secular values and work-life well being across Europe [PDF]
, 2007 This paper examines how culture, defined in our analysis by reference to traditional versus secular values, affects the work-life balance across Europe.
Georgellis, Y, Lange, T
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Work-Life Balance in a Low-Income Neighbourhood [PDF]
'Work-life balance' generally refers to how people may combine paid employment with family responsibilities. The UK government's attempts to promote work-life balance are connected to wider concerns to maximise labour-force participation and include ...
Alice Coulter, Hartley Dean
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