Results 141 to 150 of about 1,338,925 (305)

Work-life balance among IT executives in the Western Cape [PDF]

, 2019
Masters of CommerceThere has been research completed on work-life balance with a focus on women, but very little research focussed on senior management positions and especially in the IT Industry.
de Maar, Melissa Ingrid
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Work-Life Conflict Among Higher Education Institution Workers' During COVID-19: A Demands-Resources Approach. [PDF]

Front Sociol, 2022
Garraio C, Freitas JP, Magalhães SI, Matias M.   +3 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The Impact of Work–Family Conflict and Burnout on Satisfaction and Turnover Intentions Across a Middle Eastern and a European Country

Administrative Sciences
This study investigates the role of work–family conflict (WFC), family–work conflict (FWC), and two dimensions of burnout (emotional exhaustion and cynicism) in mediating the relationships between work demands and job satisfaction, life satisfaction, and
Tara Tavassoli, Albert Sunyer
doaj   +1 more source

Correction: Work-life conflict and cardiovascular health: 5-year follow-up of the Gutenberg Health Study. [PDF]

PLoS One, 2021
Hegewald J, Starke KR, Garthus-Niegel S, Schulz A, Nübling M, Latza U, Jankowiak S, Liebers F, Rossnagel K, Riechmann-Wolf M, Letzel S, Arnold N, Beutel M, Gianicolo E, Pfeiffer N, Lackner K, Münzel T, Wild P, Seidler A.   +18 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

When Work Conflicts With Personal Projects: The Association of Work-Life Conflict With Worker Wellbeing and the Mediating Role of Mindfulness. [PDF]

Front Psychol, 2021
Pacheco T, Coulombe S, Meunier S.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The Mediating Role of Work Stress between Work-Family Conflict and Work-Life Balance on Female Bank Employees

Jurnal Pamator
Finding an harmonious balance between work and personal life is a challenge for company management but also a competitive potential. This study investigates the effects of work-family conflict on work-life balance is mediated by work stress as an ...
Samitha Tariz Kusumawardani, Hesty Prima Rini   +1 more
doaj   +1 more source