Results 81 to 90 of about 40,520,256 (406)
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Further infrared systems studies for the earth resources program Final report [PDF]
Design of multispectral scanner for orbital earth resources ...
Braithwaite, J., Larsen, L., Work, E.
core +1 more source
PORTAL Journal of Multidisciplinary International Studies, 2010 This poem was inspired by long commutes I endured while holding a visiting lectureship in a neighbouring city. It explores the fine-grained tendrils of fascism in our everyday lives.
openaire +4 more sources
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Medicine Anthropology Theory, 2019 There are approximately 4.4 million direct-care workers in the United States. Comprising the labor of nurses, home health aides, certified nursing assistants, personal attendants, and companions to the elderly, direct-care work constitutes one of the ...
Alana Lee Glaser
doaj +1 more source
Constructing the 1889 Baist Atlas of Richmond, VA: Building Blocks for Digital Projects [PDF]
, 2015 The beautiful end product of a digital cultural heritage project is a wonderful thing. But building collaborative digital projects is challenging. VCU Libraries created an interactive 1889 atlas with ideas both old and new about use, access, engagement ...
Work, Lauren
core +2 more sources
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
Development of Reduced-Order Meshless Solutions of Three-Dimensional Navier Stokes Transport Phenomena [PDF]
, 2006 Emerging meshless technologies are very promising for numerically solving Euler and Navier-Stokes transport systems in one-, two-, and three-dimensions (3-D). The Reduced-Order Meshless (ROM) technique developed in this work is applicable to a wide array
Work, Daniel
core
Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases
FEBS Letters, EarlyView.
Igor Zivkovic +2 more
wiley +1 more source