Results 61 to 70 of about 3,783,867 (355)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Genetic Association Studies in Lumbar Disk Degeneration: A Systematic Review

Global Spine Journal, 2012
Introduction Low back pain (LBP) is one of the most disabling conditions associated with substantial socioeconomic and health care consequences. LBP is associated with lumbar disk degeneration, which is mainly accounted for genetic predisposition.
P. J. Eskola, S. Lemmelä, P. K. Kjaer, S. Solovieva, M. Männikkö, N. Tommerup, A. Lind-Thomsen, K. Husgafvel-Pursiainen, K. M. Cheung, D. Chan, D. Samartzis, J. Karppinen   +11 more
doaj   +1 more source

Work ability and work functioning: measuring change in individuals recently returned to work [PDF]

International Archives of Occupational and Environmental Health, 2019
To assess: (1) whether work ability and work-functioning instruments can detect relevant changes in their respective parameters following a return to work (RTW) and (2) what proportion of those returning to work show changes in their work ability and work functioning.A total of 1073 workers who returned to work after at least 2 weeks of sick leave were
A. van Schaaijk, K. Nieuwenhuijsen, M. H. W. Frings-Dresen, J. K. Sluiter   +3 more
openaire   +2 more sources

Association between work ability and fatigue in Brazilian nursing workers

, 2016
BACKGROUND: Impaired work ability is associated with work-related illnesses, early retirement and rising pension costs.\ud OBJECTIVE: To investigate the association between work ability and fatigue in nursing workers.\ud METHODS: Cross-sectional study ...
Silva, Fabio José da, Martinez, Maria Carmen, Mininel, Vivian Aline, Felli, Vanda Elisa Andres, Ratier, Ana Paula Pelegrini   +4 more
core   +1 more source

Relationships of neurosensory disorders and reduced work ability to alternative frequency weightings of hand-transmitted vibration [PDF]

, 2015
Objective This cohort study aims to compare the performance of alternative frequency weightings of handtransmitted vibration (HTV) for the assessment of the exposure–response relationships for neurosensory disorders and reduced work ability among HTV ...
BOVENZI, MASSIMO, MAURO, MARCELLA, PRODI, ANDREA   +2 more
core   +1 more source

Occupational self-efficacy and work engagement associated with work ability among an ageing work force : A cross-sectional study

, 2021
BACKGROUND: Occupational self-efficacy (OSE) is an appropriate adaption capability to react to continuous changes in work life today. While self-efficacy is an important component in work context, there is less knowledge regarding older workers' OSE ...
Rauhala, Auvo,, Nyman, Pia,, Fjellman-Wiklund, Anncristine,, Fagerström, Lisbeth,, Wallin, Stina,   +4 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The contribution of work engagement to self-perceived health, work ability, and sickness absence beyond health behaviors and work-related factors [PDF]

, 2014
Objective: To investigate whether work engagement influences self-perceived health, work ability, and sickness absence beyond health behaviors and work-related characteristics.
Robroek, S.J.W. (Suzan), Work and Organizational Psychology: Occupational Health Psychology, Schaufeli, Wilmar, Rongen, A. (Anne), Schaufeli, W.B. (Wilmar), Rongen, A, Burdorf, Lex; id_orcid, Rongen, A., Burdorf, A. (Alex), Rongen, Anne, Burdorf, Alex, Schaufeli, W, Robroek, Suzan J W, Robroek, S.JW., Robroek, Suzan, Leerstoel Schaufeli, Burdorf, Lex, Afd Sociale-,gezondheids- en organ.psych, Burdorf, A.   +18 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source