Results 61 to 70 of about 19,062,363 (287)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Association between work ability and fatigue in Brazilian nursing workers [PDF]

, 2016
BACKGROUND: Impaired work ability is associated with work-related illnesses, early retirement and rising pension costs.\ud OBJECTIVE: To investigate the association between work ability and fatigue in nursing workers.\ud METHODS: Cross-sectional study ...
Silva, Fabio José da, Martinez, Maria Carmen, Mininel, Vivian Aline, Felli, Vanda Elisa Andres, Ratier, Ana Paula Pelegrini   +4 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Genetic Association Studies in Lumbar Disk Degeneration: A Systematic Review

Global Spine Journal, 2012
Introduction Low back pain (LBP) is one of the most disabling conditions associated with substantial socioeconomic and health care consequences. LBP is associated with lumbar disk degeneration, which is mainly accounted for genetic predisposition.
P. J. Eskola, S. Lemmelä, P. K. Kjaer, S. Solovieva, M. Männikkö, N. Tommerup, A. Lind-Thomsen, K. Husgafvel-Pursiainen, K. M. Cheung, D. Chan, D. Samartzis, J. Karppinen   +11 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Effects of disturbed sleep on work ability and well-being among european nurses

, 2008
Aim: This study is aimed at assessing whether disturbed sleep predict impaired work ability and other psycho-physical work-related outcomes among European nurses working in different shift systems.
S. Sartori, G. Costa, D. Camerino, P.M. Conway   +3 more
core   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Bidirectional Assessment of Stress, job satisfaction and work ability of Educators in day care centres: a real-time observation study - the study protocol (BASE) [PDF]

, 2010
Background: Occupational demands of educators are not very well researched. Nevertheless their work is subject to several requirements. Whether these demands have an effect on the work ability and the health status of employees has also not been examined.
Nienhaus Albert, David A Groneberg, Groneberg, Jan David Alexander, Groneberg David A, Mache Stefanie, Kusma, Bianca, Michael Spallek, Mache, Stefanie, Quarcoo David, Kusma Bianca, Quarcoo, David, Bianca Kusma, David Quarcoo, Spallek, Michael, Spallek Michael, Stefanie Mache, Nienhaus, Albert, Albert Nienhaus   +17 more
core   +1 more source

Referring psychiatric patients to occupational health services for earlier return to work – a qualitative implementation study of barriers and facilitators

BMC Health Services Research
Background Mental disorders are a major public health challenge, and their prevalence is globally increasing. They substantially affect work ability, quality of life, and the number of years of disability.
Mikko Henriksson, Christina Tikka, Pirjo Juvonen-Posti, Marianna Virtanen, Tuula Oksanen   +4 more
doaj   +1 more source