Results 111 to 120 of about 985,975 (241)

Relationship between Work Ability Index and Fatigue among Iranian Critical Care Nurses

International Journal of Occupational Hygiene, 2018
Nurses have always been considered as a unique working group because of the physically and mentally demanding tasks they bear at work. Such a working condition exposes them to a high risk of fatigue, which could influence their work ability.
EHSAN GAROSI, SHARIF NAJAFI, ADEL MAZLOUMI, MOJTABA KHOSRAVI DANESH, MASOUMEH ABEDI   +4 more
doaj  

Investigation of work ability index (WAI) and its relationship with maximal aerobic capacity (VO2max) among cement industry employer

طب کار, 2020
Introduction: Given the importance of adapting workerschr('39') physical and mental capabilities to their job needs, measuring their ability to work, maintaining, and upgrading, it has become an essential task. This study aimed to investigate WAI and its
Maryam Kavousian, Ali Salehi Sahlabadi, Mohammad Javad Jafari, Soheila Khodakarim, Hadiseh Rabiei   +4 more
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

The Relationship between Fatigue and Work Ability Index (WAI) of Workers in a Ceramic Industry in Yazd Province, 2014

Archives of Occupational Health, 2018
Background: The basis of welfare and health in all individuals is their work ability. Many factors such as work and working conditions, fatigue, and individual characteristics affect the work ability.
Bahram Kouhnavard, Gholamhossein Halvani, Mohammad Reza Najimi, Hamideh Mihanpour   +3 more
doaj  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Study of relationship between Safety attitude and knowledge and The work ability index (A case study in one of the big hospitals in Tehran)

Salāmat-i kār-i Īrān, 2018
Background and aims: Knowledge of safety attitude is very important for managers of organizations, because it can be used to predict their employee safety behaviors.
Roghayeh Soleimani, Shahram Vosoughi, Taha-Hossein Hejazi, Fatemeh Mahdloo   +3 more
doaj