Results 131 to 140 of about 993,040 (277)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Skills At Work, 1986 to 2006 [PDF]

open access: yes, 2007
This report examines the skills used by British workers and highlights a significant increase in job skills over the last two decades, with computing and 'influencing' skills in particular growing in importance over the last five years.
Gallie, Duncan   +3 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Does perceived work ability improve after a multidisciplinary preventive program in a population with no severe medical problems – the Finnish Public Sector Study

open access: yesScandinavian Journal of Work, Environment & Health, 2013
OBJECTIVES: This study examines the short- and long-term effects of a multidisciplinary preventive program on perceived work ability in a population with no severe medical problems.
Mikhail Saltychev   +5 more
doaj   +1 more source

The Effect Of Work-Related Stress On Work Ability Index Among Employees In The Manufacturing Industry [PDF]

open access: yes, 2020
This study is aimed at finding the effect of Work-Related Stress on Work Ability Index among employees in the manufacturing industry. This research was done by using mixed method research where the data were collected by using questionnaires and ...
Dorothy, Isa
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Worker’s work ability index in the fruit and vegetable stands in Tehran in 2014

open access: yesپژوهان, 2015
Introduction: Now a days being involved in the jobs that are consistent with the capabilities and limitations, is one of the most important priorities of occupational health and company executives.
Mostafa Poyakian   +5 more
doaj  

[Job satisfaction and work ability index in nurses].

open access: yesLa Medicina del lavoro, 2015
Job satisfaction and work ability are important in the nursing profession to ensure good working conditions and to reduce work-related diseases and illness. Psychosocial factors such as social support and decision latitude (autonomy) could have a role in cardiovascular diseases, low back pain, injuries and sick leave.To evaluate work ability, job ...
Fiorella, Viola, Francesca, Larese Filon
openaire   +1 more source

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