Results 141 to 150 of about 20,779,634 (277)

Investigation of work ability index (WAI) and its relationship with maximal aerobic capacity (VO2max) among cement industry employer

طب کار, 2020
Introduction: Given the importance of adapting workerschr('39') physical and mental capabilities to their job needs, measuring their ability to work, maintaining, and upgrading, it has become an essential task. This study aimed to investigate WAI and its
Maryam Kavousian, Ali Salehi Sahlabadi, Mohammad Javad Jafari, Soheila Khodakarim, Hadiseh Rabiei   +4 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Assessment of quality of life, job insecurity and work ability among nurses, working either under temporary or permanent terms [PDF]

Objectives Aim of this study was to assess and compare health, quality of life, well-being, job satisfaction and job insecurity between nurses, in a tertiary hospital in Greece, working either under permanent or temporary contract.
Constantinidis, Theodoros, Aikaterini Arvaniti, Aspasia Serdari, Arvaniti, Aikaterini, Serdari, Aspasia, Katsaouni, Maria, Evangelia Nena, Theodoros Constantinidis, Maria Katsaouni, Kontogiorgis, Christos, Gregory Tripsianis, Tripsianis, Gregory, Vadikolias, Konstantinos, Nena, Evangelia, Christos Kontogiorgis, Evangelos Theodorou, Konstantinos Vadikolias, Theodorou, Evangelos   +17 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

DOES THE WORK ABILITY INDEX PREDICT RETURN TO WORK FOLLOWING A COMPENSABLE INJURY?

This study investigated whether the Work Ability Index can predict return to work for individuals (N=213) with a compensable personal injury. A binomial logistic regression analysis found that the overall Work Ability Index score explained a significant ...
James Athanasou
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The Relationship between Fatigue and Work Ability Index (WAI) of Workers in a Ceramic Industry in Yazd Province, 2014

Archives of Occupational Health, 2018
Background: The basis of welfare and health in all individuals is their work ability. Many factors such as work and working conditions, fatigue, and individual characteristics affect the work ability.
Bahram Kouhnavard, Gholamhossein Halvani, Mohammad Reza Najimi, Hamideh Mihanpour   +3 more
doaj  

Continuous vocational training and its effects on work ability

, 2011
Total Productive Maintenance (TPM) programs may improve workers’ health and safety. We studied 14 food industry workers undergoing a TPM program, and 40 health care workers with comparable work schedules not undergoing such a program.
Meloni M, COCCO, PIER LUIGI, Setzu D, DEL RIO, ALBERTO   +3 more
core