Results 161 to 170 of about 3,093,515 (308)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Exploring workability in an older working population: associations with cognitive functioning, sleep quality, and technostress

Frontiers in Public Health
ObjectiveThis observational study investigates workability and its associations with cognitive functioning, sleep quality and technostress among an older working population, also shedding light on potential differences between two occupational categories
Alice Fattori, Anna Comotti, Teresa Barnini, Cristina Di Tecco, Marco Laurino, Pasquale Bufano, Catalina Ciocan, Daniele Serra, Luca Ferrari, Matteo Bonzini, Matteo Bonzini   +10 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Relationship between Fatigue and Work Ability Index (WAI) of Workers in a Ceramic Industry in Yazd Province, 2014

Archives of Occupational Health, 2018
Background: The basis of welfare and health in all individuals is their work ability. Many factors such as work and working conditions, fatigue, and individual characteristics affect the work ability.
Bahram Kouhnavard, Gholamhossein Halvani, Mohammad Reza Najimi, Hamideh Mihanpour   +3 more
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Study of relationship between Safety attitude and knowledge and The work ability index (A case study in one of the big hospitals in Tehran)

Salāmat-i kār-i Īrān, 2018
Background and aims: Knowledge of safety attitude is very important for managers of organizations, because it can be used to predict their employee safety behaviors.
Roghayeh Soleimani, Shahram Vosoughi, Taha-Hossein Hejazi, Fatemeh Mahdloo   +3 more
doaj  

Validation of the work ability index—single item and the pain disability index—work item in patients with chronic low back pain [PDF]

, 2022
Imke Boekel, Alisa L. Dutmer, Henrica R. Schiphorst Preuper, Michiel F. Reneman   +3 more
openalex   +1 more source

Nominal Exchange Rate in Chile: Predictions based on technical analysis [PDF]

This work presents a review of the main indicators used in the technical analysis of the peso-dollar parity. We explain the usual interpretations of these indicators and we also explore the ability that the Relative Strength Index (RSI) may have to ...
Ana María Abarca G., Felipe Alarcón G., Jorge Selaive C., Pablo Pincheira B.   +3 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Work Ability Index: Validation of the Greek Version and Descriptive Data in Heavy Industry Employees

, 2013
Evangelos C. Alexopoulos
openalex   +2 more sources