Results 81 to 90 of about 938,233 (243)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Psychometric Properties of the Work Ability Index in Health Centre Workers in Spain. [PDF]

open access: yesInt J Environ Res Public Health, 2021
Mateo Rodríguez I   +4 more
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Work Ability Index of Forestry Machine Operators and some Ergonomic Aspects of their Work

open access: yesCroatian Journal of Forest Engineering, 2013
This paper provides the results of an applied research of forestry machine operators related to their work ability index (WAI) and some ergonomic aspects of their everyday work. A questionnaire on work environment and working ability was conducted in the
Ivan Martinić   +3 more
doaj  

Abilità lavorativa percepita: indagine su un campione di professionisti sanitari della riabilitazione

open access: yesJournal of Biomedical Practitioners, 2021
Obiettivo L’abilità lavorativa percepita rappresenta l’indice dell’interazione tra le risorse proprie del lavoratore e le richieste del profilo lavorativo che ricopre.
Carmelo Lorenzo Sgroi
doaj  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Individual Work Attitudes and Work Ability

open access: yesEuropean Journal of Investigation in Health, Psychology and Education
Work capacity depends on many factors, including the age and health status of the employee, but also on personal characteristics and attitudes, such as reduced tolerance of unfavorable working conditions (Work Annoyance, WA), excessive commitment to work
Nicola Magnavita   +3 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

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