Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Work Ability Among Nursing Personnel In Public Hospitals And Health Centers In Campinas--brazil.
Nursing personnel is essential in hospital, health centers and enterprises and is the large work force in health system. A cross-sectional study was conducted in a large city in two public hospitals and five health centre with the objective of to ...
Monteiro, Inês +3 more
core +2 more sources
Bidirectional Assessment of Stress, job satisfaction and work ability of Educators in day care centres: a real-time observation study - the study protocol (BASE) [PDF]
Background: Occupational demands of educators are not very well researched. Nevertheless their work is subject to several requirements. Whether these demands have an effect on the work ability and the health status of employees has also not been examined.
Nienhaus Albert +17 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Relationship between Mental Workload Index and Work Ability Index in a Food Industry
Background: Spending a significant part of the daily in workplace has led to reduction in the time of rest and recreation of people. Therefore, considering the importance of the potential effect of mental work load on work ability, the present study was ...
Nafiseh Azimi +4 more
doaj
Agentes de limpeza terceirizados: entre o ressentimento e o reconhecimento
Resumo Objetivo: analisar a percepção sobre a atividade de trabalho dos agentes de limpeza terceirizados de uma faculdade pública e determinar seu índice de capacidade para o trabalho.
Sandra Francisca Bezerra Gemma +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Effects of disturbed sleep on work ability and well-being among european nurses
Aim: This study is aimed at assessing whether disturbed sleep predict impaired work ability and other psycho-physical work-related outcomes among European nurses working in different shift systems.
S. Sartori +3 more
core +1 more source
Background: The hairdressers are exposed to musculoskeletal disorders (MSDs) due to repetitive movements in awkward postures. Objective: The aim of this study was to investigate the effective factors on MSDS prevalence and its consequents in ...
S. Ansari +4 more
doaj
OBJECTIVE: Extended working lives due to an ageing population will necessitate the maintenance of work ability across the life course. This systematic review aimed to analyze whether workplace interventions positively impact work ability.
Jodi Oakman +4 more
doaj +1 more source

