Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Psychometric Assessment of the Swedish version of the Work Ability Index in Patients with Chronic Pain in Specialized Care. [PDF]
Zetterberg H +5 more
europepmc +1 more source
Psychometric properties of Persian version of the Work Ability Index questionnaire
Objective (s): To evaluate the psychometric properties of the Persian version of Work Ability Index questionnaire (WAI).Methods: In this methodological study, a sample of nurses and healthcare staff aged 40 years and above working in educational ...
Ali Asghar Arastoo +5 more
doaj
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Assessment of work ability with the Work Ability Index (WAI) in a nursing population: a literature review [PDF]
Aim: The present research aimed to provide a systematic analysis of the work ability (WA) of nurses assessed through the Work Ability Index (WAI) with a focus on factors influencing WA in the studied population. Design: A systematic literature review. Methods: In January 2024, a literature search was performed using Medline / PubMed and ScienceDirect ...
Čukljek, Snježana +3 more
openaire
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Relation of the work ability index to fitness for work in healthcare and public employees in a region of Northeastern Italy. [PDF]
Ronchese F +8 more
europepmc +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
[Validity and reliability of the work ability index (WAI) in nurses' work].
This article assesses the validity and reliability of the work ability index (WAI) for 1,436 nurses in three public hospitals in Rio de Janeiro, Brazil. The study estimated the dimensional validity by means of exploratory factor analysis, as well as correlational validity, relating WAI to theoretically relevant constructs.
Sérgio Henrique Almeida da, Silva Junior +3 more
openaire +1 more source

