Results 171 to 180 of about 505,624 (288)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The Role of Personality in Explaining Burnout, Work Addiction, and Stress-Related Growth in Prehospital Emergency Personnel. [PDF]

Healthcare (Basel)
Butoi MA, Vancu G, Marcu RC, Hermenean A, Puticiu M, Rotaru LT.   +5 more
europepmc   +1 more source

Work Addiction in the Community: A Trend for India.

Indian J Community Med, 2021
Sharma MK, Anand N, Tadpatrikar A, Thennarasu K, Rao GN, Benegal V, Singh RL, Thomas D, Gupta HK.   +8 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Exploring Burnout, Work Addiction, and Stress-Related Growth among Prehospital Emergency Personnel. [PDF]

Behav Sci (Basel)
Puticiu M, Grecu MB, Rotaru LT, Butoi MA, Vancu G, Corlade-Andrei M, Cimpoesu D, Tat RM, Golea A.   +8 more
europepmc   +1 more source

Maladaptive Rumination Mediates the Relationship between Self-Esteem, Perfectionism, and Work Addiction: A Largescale Survey Study. [PDF]

Int J Environ Res Public Health, 2020
Kun B, Urbán R, Bőthe B, Griffiths MD, Demetrovics Z, Kökönyei G.   +5 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The International Work Addiction Scale (IWAS): A screening tool for clinical and organizational applications validated in 85 cultures from six continents. [PDF]

J Behav Addict
Charzyńska E, Buźniak A, Czerwiński SK, Woropay-Hordziejewicz N, Schneider Z, Aavik T, Adamowic M, Adams BG, Al-Mahjoob SM, Almoshawah SAS, Arrowsmith J, Asatsa S, Austin S, Aziz S, Bakker AB, Balducci C, Barros E, Bălțătescu S, Bdier D, Bhatia N, Bilic S, Boer D, Caspi A, Chaleeraktrakoon T, Chan CIM, Chien CJ, Choi HS, Choubisa R, Clark M, Čekrlija Đ, Demetrovics Z, Dervishi E, de Zoysa P, Domínguez Espinosa ADC, Dragova-Koleva S, Efstathiou V, Fernandez ME, Fernet C, Gadelrab HF, Gamsakhurdia V, Garðarsdóttir RB, Garrido LE, Gillet N, Gonçalves SP, Griffiths MD, Hakobyan NR, Halim FW, Hansenne M, Hasan BB, Herttalampi M, Hlatywayo CK, Hromatko I, Igou ER, Iliško D, Isayeva U, Ismail HN, Jensen DH, Kakupa P, Kamble S, Kerriche A, Kubicek B, Kugbey N, Kun B, Lee JH, Lisá E, Lisun Y, Lupano Perugini ML, Marcatto F, Maslovarić B, Massoudi K, McFarlane TA, Mgaiwa SJ, Moosavi Jahanabad ST, Moreta-Herrera R, Nguyen HTM, Ohtsubo Y, Özsoy T, Øvergård KI, Pallesen S, Parker J, Plohl N, Pontes HM, Potter R, Roe A, Samekin A, Schulmeyer MK, Seisembekov TZ, Serrano-Fernández MJ, Shahrour G, Matić JS, Sobhie R, Spagnoli P, Story J, Sullman MJM, Sultanova L, Sun R, Suryani AO, Sussman S, Teng-Calleja M, Torales J, Vera Cruz G, Wu AMS, Yang X, Zabrodska K, Ziedelis A, Atroszko PA.   +105 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source