Results 181 to 190 of about 179,139 (288)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Exploring Burnout, Work Addiction, and Stress-Related Growth among Prehospital Emergency Personnel. [PDF]

Behav Sci (Basel)
Puticiu M, Grecu MB, Rotaru LT, Butoi MA, Vancu G, Corlade-Andrei M, Cimpoesu D, Tat RM, Golea A.   +8 more
europepmc   +1 more source

Maladaptive Rumination Mediates the Relationship between Self-Esteem, Perfectionism, and Work Addiction: A Largescale Survey Study. [PDF]

Int J Environ Res Public Health, 2020
Kun B, Urbán R, Bőthe B, Griffiths MD, Demetrovics Z, Kökönyei G.   +5 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Work addiction and social functioning: A systematic review and five meta-analyses. [PDF]

PLoS One
Kenyhercz V, Mervó B, Lehel N, Demetrovics Z, Kun B.   +4 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The International Work Addiction Scale (IWAS): A screening tool for clinical and organizational applications validated in 85 cultures from six continents. [PDF]

J Behav Addict
Charzyńska E, Buźniak A, Czerwiński SK, Woropay-Hordziejewicz N, Schneider Z, Aavik T, Adamowic M, Adams BG, Al-Mahjoob SM, Almoshawah SAS, Arrowsmith J, Asatsa S, Austin S, Aziz S, Bakker AB, Balducci C, Barros E, Bălțătescu S, Bdier D, Bhatia N, Bilic S, Boer D, Caspi A, Chaleeraktrakoon T, Chan CIM, Chien CJ, Choi HS, Choubisa R, Clark M, Čekrlija Đ, Demetrovics Z, Dervishi E, de Zoysa P, Domínguez Espinosa ADC, Dragova-Koleva S, Efstathiou V, Fernandez ME, Fernet C, Gadelrab HF, Gamsakhurdia V, Garðarsdóttir RB, Garrido LE, Gillet N, Gonçalves SP, Griffiths MD, Hakobyan NR, Halim FW, Hansenne M, Hasan BB, Herttalampi M, Hlatywayo CK, Hromatko I, Igou ER, Iliško D, Isayeva U, Ismail HN, Jensen DH, Kakupa P, Kamble S, Kerriche A, Kubicek B, Kugbey N, Kun B, Lee JH, Lisá E, Lisun Y, Lupano Perugini ML, Marcatto F, Maslovarić B, Massoudi K, McFarlane TA, Mgaiwa SJ, Moosavi Jahanabad ST, Moreta-Herrera R, Nguyen HTM, Ohtsubo Y, Özsoy T, Øvergård KI, Pallesen S, Parker J, Plohl N, Pontes HM, Potter R, Roe A, Samekin A, Schulmeyer MK, Seisembekov TZ, Serrano-Fernández MJ, Shahrour G, Matić JS, Sobhie R, Spagnoli P, Story J, Sullman MJM, Sultanova L, Sun R, Suryani AO, Sussman S, Teng-Calleja M, Torales J, Vera Cruz G, Wu AMS, Yang X, Zabrodska K, Ziedelis A, Atroszko PA.   +105 more
europepmc   +1 more source

Exploring the Link between Work Addiction Risk and Health-Related Outcomes Using Job-Demand-Control Model. [PDF]

Int J Environ Res Public Health, 2020
Dutheil F, Charkhabi M, Ravoux H, Brousse G, Dewavrin S, Cornet T, Mondillon L, Han S, Pfabigan D, S Baker J, Mermillod M, Schmidt J, Moustafa F, Pereira B.   +13 more
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Perceived coworkers' work addiction: Scale development and associations with one's own workaholism, job stress, and job satisfaction in 85 cultures. [PDF]

J Behav Addict
Atroszko PA, Kun B, Buźniak A, Czerwiński SK, Schneider Z, Woropay-Hordziejewicz N, Bakker AB, Balducci C, Demetrovics Z, Griffiths MD, Innstrand ST, Morkevičiūtė M, Pallesen S, Pontes HM, Sussman S, Charzyńska E.   +15 more
europepmc   +1 more source