Results 71 to 80 of about 179,139 (288)

Online gaming addiction in children and adolescents: a review of empirical research

, 2012
Background and aims: Research suggests that excessive online gaming may lead to symptoms commonly experienced by substance addicts. Since games are particularly appealing to children and adolescents, these individuals may be more at risk than other ...
Kuss, DJ, Griffiths, Mark D., Griffiths, MD, Kuss, Daria J., Daria J. Kuss, Mark D. Griffiths   +5 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A continuum of disconnection: the impacts of safer supply program closures on continuity of care, transition, and total loss of service access

Harm Reduction Journal
Objective In March 2025, the expiration of federal pilot funding for Safer Supply Programs (SSPs), combined with restrictive provincial legislative changes to harm reduction service provision in Ontario, disrupted care for thousands of clients at risk of
Farihah Ali, Abigale Sprakes, Jordan Mende-Gibson, Mohammad Karamouzian, Gillian Kolla, Andrew Shaw, Andrzej Celinski, Nat Kaminski, Uppala Chandresekera, Jürgen Rehm   +9 more
doaj   +1 more source

New work on the brain and addiction

Nordic Studies on Alcohol and Drugs, 2022
Non peer ...
openaire   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Sickness presenteeism determines job satisfaction via affective-motivational states [PDF]

, 2015
Research on the consequences of sickness presenteeism, or the phenomenon of attending work whilst ill, has focused predominantly on identifying its economic, health, and absenteeism outcomes, neglecting important attitudinal-motivational outcomes.
Karanika-Murray, M., Griffiths, M.D., Biron, C, Griffiths, MD, Pontes, HM, Pontes, Halley, Karanika-Murray, M, Biron, C.   +7 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Multidimensional Work Addiction in Upper Secondary School Teachers

Multidisciplinary Journal of School Education
Research Objectives and Problems: The aim of this research is to determine the level and structure of multidimensional work addiction among the surveyed secondary school teachers.
Katarzyna Nowosad
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Internet gaming addiction - a systematic review of empirical research

, 2012
The activity of play has been ever present in human history and the Internet has emerged as a playground increasingly populated by gamers. Research suggests that a minority of Internet game players experience symptoms traditionally associated with ...
Kuss, DJ, Griffiths, MD
core   +1 more source