Results 141 to 150 of about 24,768,390 (357)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
The psychosocial work environment of nurses [PDF]
, 2012 Bakgrund: En väl fungerande psykosocial arbetsmiljö är den som anpassas efter individers behov och begränsningar. Sjuksköterskan har genom historien utsatts för hårda prövningar då yrket har setts som ett kall snarare än en profession, vilket har lett ...
Tjernberg, Therese, Waern, Caroline
core
Jurnal Bisnis dan KewirausahaanThe Balikpapan City Population and Civil Registration Office must certainly serve the community well. The provision of good service is certainly inseparable from skilled and reliable human resources.
Wiwin Pebriana +2 more
doaj +1 more source
Work environments and HIV prevention: a qualitative review and meta-synthesis of sex worker narratives [PDF]
, 2015 Shira M. Goldenberg +2 more
openalex +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Myotel: adressing motor behavior in neck shoulder pain by assessing and feedback semg in the daily (work) environment [PDF]
, 2008 Subjects with chronic pain differ in motor behavior especially with a decreased ability to relax their muscles. A myofeedback system has been developed that assesses muscle relaxation in an ambulant way during daily activities.
Hermens, H.J. +2 more
core +1 more source
Employee Loyalty Transformation: Motivation, Discipline, Work Environment, Commitment as a Moderator
Indonesian Interdisciplinary Journal of Sharia EconomicsThis study investigates the impact of work motivation, work discipline, and work environment on employee loyalty at PT Java Indosinergi Creative, with commitment serving as a mediating variable.
Tri Cicik Wijayanti
doaj +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source