Results 71 to 80 of about 3,156,114 (316)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Different levels of work-related stress and the effects on sleep, fatigue and cortisol

, 2005
Objectives The aim of the study was to relate different levels of work stress to measures of sleep and the diurnal pattern of salivary cortisol and subjective sleepiness.
Torbjörn Åkerstedt, Anna Dahlgren, Åkerstedt, Torbjörn, Göran Kecklund, Dahlgren, Anna, Kecklund, Göran   +5 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Gender-specific association between night-work exposure and type-2 diabetes: results from longitudinal study of adult health, ELSA-Brasil [PDF]

, 2015
Objectives Diabetes is a multifactorial disease of increasing prevalence. The literature suggests an impact of night work on metabolic components, though the relationship with diabetes is unclear.
Costa, Aline Silva, Nobre, Aline Araújo, Chor, Dora, Griep, Rosane Harter, Schmidt, Maria Inês, Rotenberg, Lúcia   +5 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A comparison among employees in Germany and Denmark of associations between quality of leadership and subsequent 5-year development of mental distress

Scientific Reports
We hypothesised that the association between quality of leadership and mental distress would be stronger in Germany than in Denmark. The two countries differ in terms of working life cultures and labour markets, factors possibly mitigating the ...
Hermann Burr, Norbert Kersten, Kathrine Sørensen, Jeppe K. Sørensen, Louise Dalsager, Ida E. H. Madsen, Ina Schöllgen, Angelo d’Errico, Uwe Rose, Reiner Rugulies   +9 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Agency and Adaptation: Strategies of Immigrants’ Descendants on the Swedish Labor Market

Nordic Journal of Working Life Studies, 2020
This article explores how descendants of immigrants in Sweden understand labor market conditions, and how such understandings influence their occupational strategies.
Pinar Aslan, Nader Ahmadi, Eva Wikström, Stefan Sjöberg   +3 more
doaj   +1 more source

Pivoting the Profession as We Approach the Quasquicentennial

, 2022
The year 2023 marks professional social work’s quasquicentennial: the 125th anniversary of our profession since the first social work classes were offered in the summer of 1898 at Columbia University.
Mondros, Jacqueline, Menon, Goutham M., Smyth, Nancy J., Hostetter, Carol, Teasley, Martell   +4 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source