Results 51 to 60 of about 2,119,607 (304)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

National Human Research Ethics: A Preliminary Comparative Case Study of Germany, Great Britain, Romania, and Sweden

, 2015
Although international research is increasing in volume and importance, there remains a dearth of knowledge on similarities and differences in “national human research ethics” (NHREs), that is, national ethical guidelines (NEGs), Institutional Review ...
Berman, Anne H.,, Berman, AH, Jones, Adele D., Urban, Mirjam, Schiratzki, J, Raikes, B, Schiratzki, Johanna, Foca, L, Gallagher, B, Gallagher, Bernard, Gallagher, Bernard,, Jones, Adele D.,, Ullman, Sara, Urban, Mirjam,, Foca, Liliana,, Urban, M, Raikes, Ben, Foca, Liliana, Bieganski, Justyna, Berman, Anne H., Jones, AD, Bieganski, J, Raikes, Ben,, Ullman, S, Jones, Adele, Ullman, Sara,, Bieganski, Justyna,, Ullman, Sarah, Schiratzki, Johanna,   +28 more
core   +1 more source

Co-Leadership – A Management Solution for Integrated Health and Social Care

International Journal of Integrated Care, 2016
Introduction: Co-leadership has been identified as one approach to meet the managerial challenges of integrated services, but research on the topic is limited.
Charlotte Klinga, Johan Hansson, Henna Hasson, Magna Andreen Sachs   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Justice and Responsibility: on (not) teaching computer and information ethics [PDF]

, 2003
Can we teach ethics, and if we can how should we do it? Do we want our students to know moral theory or act morally? This paper assumes that the objective of 'teaching ethics' is to cultivate the possibility for moral conduct in the everyday world of ...
Introna, L
core  

The Effects of Islamic Work Ethics and the Ethics of Love of Money over the Perception of Smuggling: The Example of the Alanya Tradesmen [PDF]

, 2016
WOS: 000439232500001This study intends to identify the thoughts of tradesmen active in commerce directed towards smuggling, which constitutes a crime in accordance with the Anti-Smuggling Act No.
Caner Güçlü, Şentürk, Faruk Kerem, Faruk Kerem Şentürk, Mehmet Bayırlı, Bayırlı, Mehmet, Güçlü, Caner   +5 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Problem or safeguard? Research ethics review in social care research and the Mental Capacity Act 2005 [PDF]

, 2010
Information: Title: Problem or safeguard? Research ethics review in social care research and the Mental Capacity Act 2005 Author(s): Jonathan Parker, (Bournemouth University, UK), Bridget Penhale, (University of Sheffield, UK), David Stanley ...
Stanley, David, Bridget Penhale, Penhale, B., Stanley, D., Penhale, Bridget, Parker, J., Parker, Jonathan, David Stanley, Jonathan Parker   +8 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source