Results 121 to 130 of about 27,156,344 (411)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

THE COLLABORATION BETWEEN THE PEDAGOGUE AND TEACHERS IN THE FUNCTION OF IMPROVING THE TEACHING WORK

, 2023
Sanja Gacov
openalex   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

3D Topological Inorganic Electrides: Screening, Properties, and Applications

Advanced Science
The convergence of inorganic electrides and topological quantum phenomena has ushered in novel paradigms for designing advanced quantum materials. While low‐dimensional (0–2D) topological inorganic electrides have garnered considerable attention, their ...
Zhenzhou Guo, Weizhen Meng, Qianwen Zhang, Xia Cheng, Shiyao Wang, Yalong Jiao, Xiaoming Zhang, Ying Liu, Tie Yang   +8 more
doaj   +1 more source

Heart rate variability and endothelial function after sleep deprivation and recovery sleep among male shift and non-shift workers.

, 2017
OBJECTIVES: Endothelial dysfunction and alterations in heart rate variability (HRV) as well as sleep deprivation and shift work have been associated with cardiovascular disease.
Skene, DJ, Wehrens, SM, Hampton, SM
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The influence of hole states on the electronic and electrostatic properties of 2D layers based on the silicon-germaniumsilicon heterostructure

St. Petersburg Polytechnical University Journal: Physics and Mathematics
The performance of a hole qubit in the Si/Ge/Si heterostructure is considered in this work. For this purpose, a quantum mechanical study using density functional theory and the pseudopotential method has been carried out.
Obrazcov Kirill, Chibisov Andrey, Mamonova Marina   +2 more
doaj   +1 more source

Strain effects on the work function of an organic semiconductor

Nature Communications, 2016
Establishing fundamental relationships between strain and work function (WF) in organic semiconductors is important not only for understanding electrical properties of organic thin films, which are subject to both intrinsic and extrinsic strains, but ...
Yanfei Wu, Annabel R. Chew, Geoffrey A. Rojas, G. Sini, G. Haugstad, A. Belianinov, Sergei V. Kalinin, Hong Li, C. Risko, J. Brédas, A. Salleo, C. Frisbie   +11 more
semanticscholar   +1 more source