Results 131 to 140 of about 22,567,699 (313)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Adsorbate-induced Work Function Changes
, 1972 The model for adsorbate-induced work function changes developed by Gyftopoulos and Levine1) is shown to quantitatively predict increased work function changes for adsorption of silicon and boron on tungsten substrates.
Ownby, P. D., Flaim, Thomas A.
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In Situ Bipolar Doping via Mechanically Controlled Dipole Under Water
Advanced Materials InterfacesPolycrystalline silicon (poly‐Si) is essential in integrated circuits and microelectromechanical systems. In addition, poly‐Si is gaining attention for next‐generation display research with high thermal conductivity, stability, and versatile applications.
Sanghwan Choi, Gunhoo Woo, Taesung Kim
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
United War Work Campaign Opening Rally pamphlet, November 8, 1918
, 1918 This 20-page pamphlet is for the Opening Rally of the United War Work Campaign held on November 8, 1918. The rally was held at the Medinah Temple in Chicago. The pamphlet has the order of events, posters used by all seven of the organizations involved in
United War Work Campaign;
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Social Work Practice with Populations at Risk [PDF]
, 1988 The University Archives has determined that this item is of continuing value to OSU's history.The Ohio State University College of Social WorkProceedings title page, table of contents, and ...
Ohio State University. College of Social Work
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
, 2018 In this work, the tunnel oxide passivated contact (TOPCon) with a low-work-function electron-selective-collection (ESC) layer is studied using a numerical simulation method.
Yan, Baojie +10 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source